Cell Therapy Translational Research Laboratory, University Health Network (UHN), Toronto, Ontario, Canada.
Arthritis Program, Krembil Research Institute, UHN, Toronto, ON, Canada.
Stem Cells. 2018 Nov;36(11):1655-1662. doi: 10.1002/stem.2902. Epub 2018 Oct 13.
Mesenchymal stromal cells (MSCs) deploy Toll-like receptors (TLRs) to respond to exogenous and endogenous signals. Activation of TLR pathways in MSCs alters their inflammatory profile and immunomodulatory effects on cells from both the innate and adaptive immune systems. Micro-RNAs (miRNAs), whose expression is modulated by TLR activation, can regulate inflammatory responses by targeting components of the TLR signaling pathways either in MSCs or in the cells with which they interact. Here, we review how the miRNA-TLR pathway axis can regulate the immunomodulatory functions of MSCs, including their interactions with monocytes/macrophages and natural killer cells, and discuss the therapeutic implications for MSC-based therapies. Stem Cells 2018;36:1655-1662.
间充质基质细胞 (MSCs) 通过 Toll 样受体 (TLRs) 来响应外源性和内源性信号。MSCs 中 TLR 途径的激活改变了它们的炎症特征和对固有免疫和适应性免疫系统细胞的免疫调节作用。微 RNA（miRNAs）的表达受 TLR 激活的调节，它们可以通过靶向 TLR 信号通路的组成部分来调节炎症反应，无论是在 MSCs 中还是在与它们相互作用的细胞中。在这里，我们综述了 miRNA-TLR 通路轴如何调节 MSCs 的免疫调节功能，包括它们与单核细胞/巨噬细胞和自然杀伤细胞的相互作用，并讨论了基于 MSC 的治疗的治疗意义。干细胞 2018；36:1655-1662。
