Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Semin Cell Dev Biol. 2019 Aug;92:89-96. doi: 10.1016/j.semcdb.2018.08.012. Epub 2018 Sep 5.
Pancreas organogenesis depends on proper interactions of endoderm-derived epithelial cells, which will form the exocrine and endocrine cells of the adult organ, with their surrounding mesenchymal layer. Research on the role of pancreatic mesenchyme, pioneered by Golosow and Grobstein in the 1960's, revealed these cells regulate multiple events during pancreas development. Still, much is unknown regards the molecular basis of epithelial-mesenchymal interactions in this process. Here, we review in vivo and ex vivo approaches to study mesenchymal requirements for mammal pancreas organogenesis, and how gained knowledge is being translated toward the development of cell replacement therapy for diabetes.
胰腺器官发生依赖于内胚层衍生的上皮细胞的适当相互作用，这些细胞将形成成年器官的外分泌和内分泌细胞，与它们周围的间质层相互作用。20 世纪 60 年代，Golosow 和 Grobstein 开创的关于胰腺间质的研究揭示了这些细胞在胰腺发育过程中调节多种事件。尽管如此，对于这个过程中上皮-间充质相互作用的分子基础，仍有很多未知。在这里，我们回顾了体内和体外研究哺乳动物胰腺器官发生中间质需求的方法，以及获得的知识如何转化为糖尿病细胞替代治疗的发展。
