双组分调控系统在β-内酰胺类抗生素耐药中的作用。

The role of two-component regulatory system in β-lactam antibiotics resistance.

机构信息

Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety/Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, the Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China.

出版信息

Microbiol Res. 2018 Oct;215:126-129. doi: 10.1016/j.micres.2018.07.005. Epub 2018 Jul 19.

DOI:10.1016/j.micres.2018.07.005

PMID:30172298

Abstract

The irrational use of antibiotics in agriculture and in the medical field has led to a variety of pathogenic microorganisms that produce drug resistance and even multidrug resistance. B-lactam is one of the most widely used antibiotics to treat infectious diseases. Resistance to β-lactam resistance can be primarily due to the presence β-lactamase, mutation of β-lactam targets and overexpression of efflux pumps. Two-component regulatory systems are composed of histidine kinase and response regulator that regulate gene expression under different environmental conditions. In this review, we summarized the mechanisms by which β-lactam resistance is developed and the role of the two-component regulatory system in β-lactam resistance.

摘要

抗生素在农业和医疗领域的不合理使用导致了各种产生耐药性甚至多药耐药性的致病微生物。β-内酰胺类抗生素是治疗感染性疾病最广泛使用的抗生素之一。对β-内酰胺类抗生素的耐药性主要可以归因于β-内酰胺酶的存在、β-内酰胺类靶标突变和外排泵的过度表达。双组分调节系统由组氨酸激酶和反应调节剂组成，可在不同环境条件下调节基因表达。在这篇综述中，我们总结了β-内酰胺类抗生素耐药性产生的机制以及双组分调节系统在β-内酰胺类抗生素耐药性中的作用。