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截至2017年,由美国总统艾滋病紧急救援计划支持的男性自愿医学包皮环切术在预防艾滋病方面取得的进展:纵向及近期横断面项目数据

Progress in voluntary medical male circumcision for HIV prevention supported by the US President's Emergency Plan for AIDS Relief through 2017: longitudinal and recent cross-sectional programme data.

作者信息

Davis Stephanie M, Hines Jonas Z, Habel Melissa, Grund Jonathan M, Ridzon Renee, Baack Brittney, Davitte Jonathan, Thomas Anne, Kiggundu Valerian, Bock Naomi, Pordell Paran, Cooney Caroline, Zaidi Irum, Toledo Carlos

机构信息

Division of Global HIV and TB, HIV Prevention Branch, Voluntary Medical Male Circumcision Team, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

President's Emergency Plan for AIDS Relief, Office of the U.S. Global AIDS Coordinator and Health Diplomacy, Washington, District of Columbia, USA.

出版信息

BMJ Open. 2018 Sep 1;8(8):e021835. doi: 10.1136/bmjopen-2018-021835.

Abstract

OBJECTIVE

This article provides an overview and interpretation of the performance of the US President's Emergency Plan for AIDS Relief's (PEPFAR's) male circumcision programme which has supported the majority of voluntary medical male circumcisions (VMMCs) performed for HIV prevention, from its 2007 inception to 2017, and client characteristics in 2017.

DESIGN

Longitudinal collection of routine programme data and disaggregations.

SETTING

14 countries in sub-Saharan Africa with low baseline male circumcision coverage, high HIV prevalence and PEPFAR-supported VMMC programmes.

PARTICIPANTS

Clients of PEPFAR-supported VMMC programmes directed at males aged 10 years and above.

MAIN OUTCOME MEASURES

Numbers of circumcisions performed and disaggregations by age band, result of HIV test offer, procedure technique and follow-up visit attendance.

RESULTS

PEPFAR supported a total of 15 269 720 circumcisions in 14 countries in Southern and Eastern Africa. In 2017, 45% of clients were under 15 years of age, 8% had unknown HIV status, 1% of those tested were HIV+ and 84% returned for a follow-up visit within 14 days of circumcision.

CONCLUSIONS

Over 15 million VMMCs have been supported by PEPFAR since 2007. VMMC continues to attract primarily young clients. The non-trivial proportion of clients not testing for HIV is expected, and may be reassuring that testing is not being presented as mandatory for access to circumcision, or in some cases reflect test kit stockouts or recent testing elsewhere. While VMMC is extremely safe, achieving the highest possible follow-up rates for early diagnosis and intervention on complications is crucial, and programmes continue to work to raise follow-up rates. The VMMC programme has achieved rapid scale-up but continues to face challenges, and new approaches may be needed to achieve the new Joint United Nations Programme on HIV/AIDS goal of 27 million additional circumcisions through 2020.

摘要

目的

本文概述并解读了美国总统艾滋病紧急救援计划(PEPFAR)的男性包皮环切项目的实施情况,该项目自2007年启动至2017年,为大多数出于预防艾滋病目的而进行的自愿医学男性包皮环切术(VMMC)提供了支持,并介绍了2017年的客户特征。

设计

对常规项目数据进行纵向收集和分类。

背景

撒哈拉以南非洲的14个国家,这些国家男性包皮环切术的基线覆盖率较低,艾滋病病毒感染率较高,且有PEPFAR支持的VMMC项目。

参与者

PEPFAR支持的针对10岁及以上男性的VMMC项目的客户。

主要观察指标

包皮环切术的实施数量以及按年龄组、艾滋病病毒检测结果、手术技术和随访就诊情况进行的分类。

结果

PEPFAR在南部和东部非洲的14个国家共支持了15269720例包皮环切术。2017年,45%的客户年龄在15岁以下,8%的客户艾滋病病毒感染状况不明,接受检测的客户中有1%为艾滋病病毒阳性,84%的客户在包皮环切术后14天内返回进行随访。

结论

自2007年以来,PEPFAR已支持超过1500万例VMMC。VMMC主要吸引的仍是年轻客户。未进行艾滋病病毒检测的客户比例不可忽视,这可能令人安心,说明检测并非接受包皮环切术的强制要求,或者在某些情况下反映了检测试剂盒缺货或近期在其他地方已进行检测。虽然VMMC极其安全,但实现尽可能高的随访率以进行并发症的早期诊断和干预至关重要,各项目仍在努力提高随访率。VMMC项目已实现快速扩大规模,但仍面临挑战,可能需要新的方法来实现联合国艾滋病规划署的新目标,即到2020年再增加2700万例包皮环切术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f5/6120649/124fee73986e/bmjopen-2018-021835f01.jpg

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