School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
Affiliated Hospital, Taishan Medical University, Taian, Shandong, China.
Neurobiol Aging. 2018 Dec;72:189.e1-189.e9. doi: 10.1016/j.neurobiolaging.2018.08.008. Epub 2018 Aug 10.
Alzheimer's disease (AD) is the leading cause of dementia in older adults. It is more than 50 years since vitamin E was recognized as critical for optimal neurological health. Clinical studies have yielded inconsistent findings on the effect of vitamin E on AD risk. Thus, it remains unclear whether vitamin E levels are genetically associated with AD risk. We performed a Mendelian randomization study to investigate association of circulating vitamin E levels with AD using large-scale vitamin E genome-wide association study data set (N = 7781 individuals of European descent) and AD genome-wide association study data set (N = 54,162 individuals [including 17,008 AD cases and 37,154 controls of European descent]). Mendelian randomization-Egger intercept test showed no significant pleiotropy (β = -0.113; p = 0.296). Inverse-variance weighted (odds ratio = 0.96, 95% confidence interval: 0.47-1.94, p = 0.936) and weighted median analyses (odds ratio = 1.13, 95% confidence interval: 0.35-3.69, p = 0.836) showed no significant association between vitamin E and AD. Together with previous literature, this suggests that vitamin E supplementation may not forestall AD in the general population.
阿尔茨海默病（AD）是导致老年人痴呆的主要原因。自 50 多年前发现维生素 E 对最佳神经健康至关重要以来。关于维生素 E 对 AD 风险的影响，临床研究得出的结果并不一致。因此，目前尚不清楚维生素 E 水平是否与 AD 风险存在遗传相关性。我们进行了一项孟德尔随机化研究，使用大规模的维生素 E 全基因组关联研究数据集（N=7781 名欧洲血统个体）和 AD 全基因组关联研究数据集（N=54162 名个体[包括 17008 名 AD 病例和 37154 名欧洲血统对照]），调查循环维生素 E 水平与 AD 的关联。孟德尔随机化-Egger 截距检验未显示出明显的多效性（β=-0.113；p=0.296）。逆方差加权（比值比=0.96，95%置信区间：0.47-1.94，p=0.936）和加权中位数分析（比值比=1.13，95%置信区间：0.35-3.69，p=0.836）均未显示维生素 E 与 AD 之间存在显著关联。结合以往的文献，这表明维生素 E 补充剂可能无法预防普通人群患 AD。
