Wang Xiaolan, Lv Yue, Li Wen, Gan Chen, Chen Haijun, Liu Yingying, Chao Herta H, Li Chiang-Shan R, Cheng Huaidong
Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei, Anhui 230601, China.
Cancer Hospital, Hefei Institutes of Physical Science, Chinese Academy of Sciences, No. 350, Shushan Hu Road, Hefei, Anhui 230031, China.
J Oncol. 2018 Aug 6;2018:3625302. doi: 10.1155/2018/3625302. eCollection 2018.
The aim of this study was to investigate the relationship between psychosocial distress and quality of life (QOL) in patients with nasopharyngeal carcinoma (NPC) after radiotherapy. Fifty-three patients with an initial diagnosis of NPC were enrolled in this study. The psychological Distress Thermometer (DT) and Functional Assessment of Cancer Therapy-Head & Neck (FACT-H&N) were conducted before and after radiotherapy in NPC patients. We compared the differences in psychological distress and QOL before and after radiotherapy and analyzed the correlation between psychological distress and QOL after radiotherapy. The performance on the DT was 6.60 ± 1.42 and 2.81 ± 1.43 before and after chemotherapy, respectively, with a significant difference between the time points (t = -13.73, < 0.01). The performance on the FACT-H&N was 68.30 ± 6.14 and 39.84 ± 6.14 before and after chemotherapy, respectively, with a significant difference between the time points (t = -19.9, < 0.01). There was a significant negative correlation between the DT score and the FACT-H&N score (r = -3.64, < 0.01). Patients with NPC experience different degrees of psychological distress, an important factor that affects quality of life, after radiotherapy.
本研究旨在调查鼻咽癌（NPC）患者放疗后心理社会困扰与生活质量（QOL）之间的关系。53例初诊为NPC的患者纳入本研究。对NPC患者在放疗前后进行心理困扰温度计（DT）和癌症治疗功能评估-头颈版（FACT-H&N）。我们比较了放疗前后心理困扰和生活质量的差异，并分析了放疗后心理困扰与生活质量之间的相关性。化疗前后DT的表现分别为6.60±1.42和2.81±1.43，时间点之间存在显著差异（t=-13.73，<0.01）。化疗前后FACT-H&N的表现分别为68.30±6.14和39.84±6.14，时间点之间存在显著差异（t=-19.9，<0.01）。DT评分与FACT-H&N评分之间存在显著负相关（r=-3.64，<0.01）。NPC患者放疗后经历不同程度的心理困扰，这是影响生活质量的一个重要因素。
