通过面食结构的复制成型在课堂上制造微流控系统。
"Do-it-in-classroom" fabrication of microfluidic systems by replica moulding of pasta structures.
作者信息
Nguyen Ngan, Thurgood Peter, Zhu Jiu Yang, Pirogova Elena, Baratchi Sara, Khoshmanesh Khashayar
机构信息
School of Engineering, RMIT University, Melbourne, Victoria 3000, Australia.
School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria 3083, Australia.
出版信息
Biomicrofluidics. 2018 Aug 20;12(4):044115. doi: 10.1063/1.5042684. eCollection 2018 Jul.
Here, we describe a novel method for fabrication of microfluidic structures in classroom environments. This method is based on replica moulding of pasta structures in polydimethylsiloxane. Placing pasta structures on a petroleum jelly base layer enables templating round-shaped structures with controllable cross-sectional profiles. The pasta structures can be easily deformed and combined to create more complex 3D microfluidic structures. Proof-of-concept experiments indicate the capability of this method for studying the mixing of neighbouring flows, generation of droplets, lateral migration of particles, as well as culturing, shear stress stimulation, and imaging of cells. Our "do-it-in-classroom" method bridges the gap between the classroom and the laboratory.
在这里，我们描述了一种在课堂环境中制造微流体结构的新方法。该方法基于在聚二甲基硅氧烷中复制面食结构。将面食结构放置在凡士林基层上能够制作出具有可控横截面轮廓的圆形结构。面食结构可以很容易地变形和组合，以创建更复杂的三维微流体结构。概念验证实验表明，该方法能够用于研究相邻流的混合、液滴的生成、颗粒的横向迁移，以及细胞的培养、剪切应力刺激和成像。我们的“课堂动手做”方法弥合了课堂与实验室之间的差距。
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