Venkatesulu Bhanu Prasad, Mahadevan Lakshmi Shree, Aliru Maureen L, Yang Xi, Bodd Monica Himaani, Singh Pankaj K, Yusuf Syed Wamique, Abe Jun-Ichi, Krishnan Sunil
Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
JACC Basic Transl Sci. 2018 Aug 28;3(4):563-572. doi: 10.1016/j.jacbts.2018.01.014. eCollection 2018 Aug.
In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by vascular endothelial injury. Radiation both initiates and accelerates atherosclerosis, leading to vascular events like stroke, coronary artery disease, and peripheral artery disease. Increased levels of proinflammatory cytokines in the blood of long-term survivors of the atomic bomb suggest that radiation evokes a systemic inflammatory state responsible for chronic vascular side effects. In this review, the authors offer an overview of potential mechanisms implicated in radiation-induced vascular injury.
在癌症放射治疗中，治疗比代表了肿瘤控制与正常组织并发症之间的最佳平衡。随着抗癌治疗手段的改进延长了患者寿命，放射治疗晚期效应的重要性日益增加，尤其是由血管内皮损伤引起的那些效应。辐射既引发又加速动脉粥样硬化，导致中风、冠状动脉疾病和外周动脉疾病等血管事件。原子弹长期幸存者血液中促炎细胞因子水平升高表明，辐射引发了一种全身性炎症状态，这种状态导致了慢性血管副作用。在这篇综述中，作者概述了辐射诱导血管损伤所涉及的潜在机制。
