Department of Polymer Materials, College of Materials Science and Engineering, Shanghai University, Shanghai 200444, China.
Chem Soc Rev. 2018 Sep 17;47(18):6900-6916. doi: 10.1039/c7cs00841d.
Self-immolative chemistry features a cascade of disassembly reactions in response to external stimuli, which provides great opportunities to design new self-immolative chemosensors with advanced performance and/or functions. Self-immolative spacers in these chemosensors not only facilitate the linkage of designed triggers to various chromophores or fluorophores, but can also be used to solve inherent problems associated with native chemosensors, such as low reactivities, poor stabilities and slow response times. Their capacity for stimuli-responsive release through operation of a self-immolative reaction further enables integration of sophisticated functions into chemosensors, including signal amplification, enzyme activity localization, and drug monitoring. Significant advances have been made in the field of self-immolative chemosensors, leading to intriguing applications to sensitive detection of analytes, bioimaging and cancer theranostics. This tutorial review summarizes this recent progress with a focus on their design strategies and sensing mechanisms.
自毁化学的特点是一系列的分解反应，以响应外部刺激，这为设计具有先进性能和/或功能的新型自毁化学传感器提供了巨大的机会。这些化学传感器中的自毁间隔物不仅便于将设计的触发物连接到各种生色团或荧光团，而且还可以用于解决与天然化学传感器相关的固有问题，例如反应性低、稳定性差和响应时间慢。它们通过自毁反应的操作进行刺激响应释放的能力进一步使复杂的功能集成到化学传感器中，包括信号放大、酶活性定位和药物监测。在自毁化学传感器领域取得了重大进展，引起了对分析物的敏感检测、生物成像和癌症治疗的有趣应用。本综述总结了这方面的最新进展，重点介绍了它们的设计策略和传感机制。
