State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin, 300130, PR China; Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
Colloids Surf B Biointerfaces. 2018 Dec 1;172:308-314. doi: 10.1016/j.colsurfb.2018.08.051. Epub 2018 Aug 24.
The biomineralized bacterial magnetic nanoparticles (BMPs) have been widely studied for biomedical applications with their magnetic properties and a layer of biomembrane. Herein, BMPs were firstly used for magnetically targeted photothermal cancer therapy in vivo. A self-build C-shaped bipolar permanent magnet was used for magnetic targeting though the generation of a high gradient magnetic field within a small target area. For in vitro simulated experiment, BMPs had a high retention rate in magnetically targeted region with different flow rates. In H22 tumor bearing mice, the magnetic targeting induced a 40% increase of BMPs retention in tumor tissues. In vivo photothermal therapy with 808 nm laser irradiation could induce a complete tumor elimination with magnetic targeting. These results indicated that the systematically administrated BMPs with magnetic targeting would be promising for photothermal cancer therapy.
生物矿化细菌磁性纳米颗粒（BMPs）因其磁性和一层生物膜而被广泛研究用于生物医学应用。本文首次将 BMPs 用于体内磁靶向光热癌症治疗。通过在小目标区域内产生高梯度磁场，使用自行构建的 C 形双极永磁体进行磁靶向。在体外模拟实验中，BMPs 在不同流速下仍能在磁靶向区域保持高保留率。在荷 H22 肿瘤的小鼠中，磁靶向诱导肿瘤组织中 BMPs 保留增加了 40%。用 808nm 激光照射进行体内光热治疗，磁靶向可完全消除肿瘤。这些结果表明，系统给予具有磁靶向的 BMPs 有望用于光热癌症治疗。
