文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

用于磁共振/光声成像引导的磁靶向光热治疗的智能二硫化钼/四氧化三铁纳米诊疗剂

Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.

作者信息

Yu Jie, Yin Wenyan, Zheng Xiaopeng, Tian Gan, Zhang Xiao, Bao Tao, Dong Xinghua, Wang Zhongliang, Gu Zhanjun, Ma Xiaoyan, Zhao Yuliang

机构信息

1. Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, Shaanxi, China ; 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China.

2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Beijing, China.

出版信息

Theranostics. 2015 May 20;5(9):931-45. doi: 10.7150/thno.11802. eCollection 2015.

DOI:10.7150/thno.11802
PMID:26155310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4493532/
Abstract

The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.

摘要

在癌症治疗过程中，能够选择性地破坏癌细胞同时保留正常组织是非常理想的。在此，通过将二硫化钼（MS）薄片与四氧化三铁（IO）纳米颗粒（NPs）相结合，展示了磁靶向光热疗法，其中二硫化钼将近红外（NIR）光转化为热量，四氧化三铁纳米颗粒作为在外部磁场引导下靶向肿瘤部位的部分。通过简单的两步水热法制备了由生物相容性聚乙二醇（PEG）功能化的二硫化钼/四氧化三铁复合材料（MSIOs）。所获得的MSIOs在生物流体中表现出高稳定性，在体外和体内均具有低毒性。具体而言，由于其超顺磁性和强烈的近红外吸收，MSIOs可作为用于T2加权磁共振（MR）和光声断层扫描（PAT）成像的双模态探针。此外，我们展示了对癌症进行磁靶向光热消融的有效结果。所有这些结果表明，在磁场的空间/时间引导下对癌症进行局部光热消融具有巨大潜力，并表明多功能MSIOs在癌症诊疗中的应用前景广阔。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/01d92e9b499e/thnov05p0931g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/037e13431f34/thnov05p0931g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/0f2a2bcaffb0/thnov05p0931g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/ae8a37ba9e9e/thnov05p0931g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/281ea57bac80/thnov05p0931g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/1e153d6ac0a7/thnov05p0931g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/b8e72a621bdf/thnov05p0931g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/895fc9863c10/thnov05p0931g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/c58d2a9df24d/thnov05p0931g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/8d60a4044b95/thnov05p0931g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/01d92e9b499e/thnov05p0931g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/037e13431f34/thnov05p0931g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/0f2a2bcaffb0/thnov05p0931g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/ae8a37ba9e9e/thnov05p0931g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/281ea57bac80/thnov05p0931g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/1e153d6ac0a7/thnov05p0931g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/b8e72a621bdf/thnov05p0931g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/895fc9863c10/thnov05p0931g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/c58d2a9df24d/thnov05p0931g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/8d60a4044b95/thnov05p0931g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d47/4493532/01d92e9b499e/thnov05p0931g010.jpg

相似文献

[1]
Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.

Theranostics. 2015-5-20

[2]
Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy.

ACS Nano. 2015-1-27

[3]
Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy.

J Control Release. 2017-5-10

[4]
Multifunctional NIR-responsive poly(vinylpyrrolidone)-Cu-Sb-S nanotheranostic agent for photoacoustic imaging and photothermal/photodynamic therapy.

Acta Biomater. 2018-5-9

[5]
Copper Manganese Sulfide Nanoplates: A New Two-Dimensional Theranostic Nanoplatform for MRI/MSOT Dual-Modal Imaging-Guided Photothermal Therapy in the Second Near-Infrared Window.

Theranostics. 2017-10-17

[6]
Biocompatible PEGylated bismuth nanocrystals: "All-in-one" theranostic agent with triple-modal imaging and efficient in vivo photothermal ablation of tumors.

Biomaterials. 2017-6-23

[7]
Förster Resonance Energy Transfer-Based Dual-Modal Theranostic Nanoprobe for Visualization of Cancer Photothermal Therapy.

Theranostics. 2018-1-1

[8]
Monodisperse Au-FeC Janus Nanoparticles: An Attractive Multifunctional Material for Triple-Modal Imaging-Guided Tumor Photothermal Therapy.

ACS Nano. 2017-9-5

[9]
Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy.

Theranostics. 2015-7-25

[10]
Controllable growth of Au nanostructures onto MoS nanosheets for dual-modal imaging and photothermal-radiation combined therapy.

Nanoscale. 2019-11-21

引用本文的文献

[1]
MoS-Based nanocomposite for synergistic chemo-photothermal cancer therapy.

Sci Rep. 2025-7-2

[2]
Iron oxide nanoparticles in leukemia: design, diagnostic applications, and therapeutic strategies.

J Egypt Natl Canc Inst. 2025-6-3

[3]
Comparison of structural, optical, and thermal properties in MoS based nanocomposites into cancer therapy.

J Mater Sci Mater Med. 2025-4-25

[4]
Periodic Table of Immunomodulatory Elements and Derived Two-Dimensional Biomaterials.

Adv Sci (Weinh). 2025-2

[5]
Improvement photothermal property of MoS/FeO/GNR nanocomposite in cancer treatment.

J Mater Sci Mater Med. 2024-8-13

[6]
Multimodal optoacoustic imaging: methods and contrast materials.

Chem Soc Rev. 2024-6-17

[7]
Superparamagnetic MoS@FeO nanoflowers for rapid resonance-Raman scattering biodetection.

J Mater Sci Mater Electron. 2022

[8]
Advances in Atherosclerosis Theranostics Harnessing Iron Oxide-Based Nanoparticles.

Adv Sci (Weinh). 2024-5

[9]
Interfacial Charge Transfer Effects of MoS/α-FeO Nano-Heterojunction and Efficient Photocatalytic Hydrogen Evolution under Visible-Light Irradiation.

Nanomaterials (Basel). 2023-10-15

[10]
Conjugated Nanoparticles for Solid Tumor Theranostics: Unraveling the Interplay of Known and Unknown Factors.

ACS Omega. 2023-10-5

本文引用的文献

[1]
Iron oxide decorated MoS2 nanosheets with double PEGylation for chelator-free radiolabeling and multimodal imaging guided photothermal therapy.

ACS Nano. 2015-1-27

[2]
Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor.

ACS Nano. 2015-1-12

[3]
Hyaluronic acid-modified Fe3O4@Au core/shell nanostars for multimodal imaging and photothermal therapy of tumors.

Biomaterials. 2014-11-9

[4]
Erythrocyte membrane is an alternative coating to polyethylene glycol for prolonging the circulation lifetime of gold nanocages for photothermal therapy.

ACS Nano. 2014-10-9

[5]
High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy.

ACS Nano. 2014-6-16

[6]
Mesoporous magnetic gold "nanoclusters" as theranostic carrier for chemo-photothermal co-therapy of breast cancer.

Theranostics. 2014-4-4

[7]
Near-infrared light-responsive nanomaterials in cancer therapeutics.

Chem Soc Rev. 2014-9-7

[8]
Radioactive 198Au-doped nanostructures with different shapes for in vivo analyses of their biodistribution, tumor uptake, and intratumoral distribution.

ACS Nano. 2014-5-27

[9]
Drug delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer.

Adv Mater. 2014-2-20

[10]
Multifunctional Fe5 C2 nanoparticles: a targeted theranostic platform for magnetic resonance imaging and photoacoustic tomography-guided photothermal therapy.

Adv Mater. 2014-3-26

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索