Division of Infectious Diseases, Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
Division of Infectious Diseases, Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
J Microbiol Immunol Infect. 2019 Apr;52(2):352-362. doi: 10.1016/j.jmii.2018.08.001. Epub 2018 Aug 22.
BACKGROUND/PURPOSE: The health risks of environmental heavy metals have been of concern are well known. The greater likelihood of heavy metal contamination in the physical environment increases the risk of asthma, especially in children. This cross-sectional, population-based study sought to investigate associations between heavy metal exposure and childhood asthma or wheezing.
Data from 5866 subjects, stratified into age groups of 2-5, 6-11, and 12-15 years, from the National Health and Nutrition Examination Survey 2007-2012 conducted by the Centers for Disease Control and Prevention were analyzed retrospectively. The primary outcome was active asthma. Variables included demographics, anthropometric, and clinical data. Univariate and multivariate logistic regression analyses were used to identify associations between blood heavy metal concentrations and adjusted odds (aORs) of active asthma.
Higher concentration of blood lead was associated with higher adjusted odds of having asthma (aOR = 1.08, 95% CI = 1.00-1.16), but no significant effect was shown for current wheezing or whistling. Age-stratified analysis showed that higher blood lead concentration was associated with higher risk for active asthma (aOR = 1.24, 95% CI = 1.08-1.42) and current wheezing or whistling (aOR = 1.19, 95% CI = 1.04-1.38) in the 6-11 years age group, while higher blood mercury concentration was associated with lower risk of current wheezing or whistling (aOR = 0.95, 95% CI = 0.90-0.99). The medium concentration of blood lead was associated with decreased risks of current wheezing or whistling (aOR = 0.54, 95% CI = 0.30-0.96) in the 2-5 years age group.
Higher concentrations of blood lead are associated with higher odds of asthma in children aged 2-15 years.
背景/目的：众所周知，环境重金属的健康风险令人担忧。物理环境中重金属污染的可能性越大，患哮喘的风险就越高，尤其是在儿童中。本横断面、基于人群的研究旨在调查重金属暴露与儿童哮喘或喘息之间的关系。
从疾病控制与预防中心进行的 2007-2012 年全国健康和营养检查调查中，回顾性分析了年龄组为 2-5 岁、6-11 岁和 12-15 岁的 5866 名受试者的数据。主要结果是活动性哮喘。变量包括人口统计学、人体测量学和临床数据。使用单变量和多变量逻辑回归分析来确定血液重金属浓度与调整后的活跃哮喘比值比（aOR）之间的关联。
血液铅浓度较高与患哮喘的调整后比值比较高相关（aOR=1.08，95%CI=1.00-1.16），但当前喘息或哨声无显著影响。年龄分层分析显示，较高的血液铅浓度与 6-11 岁年龄组的活跃哮喘（aOR=1.24，95%CI=1.08-1.42）和当前喘息或哨声（aOR=1.19，95%CI=1.04-1.38）的风险增加相关，而较高的血液汞浓度与当前喘息或哨声的风险降低相关（aOR=0.95，95%CI=0.90-0.99）。血液铅的中浓度与 2-5 岁年龄组当前喘息或哨声的风险降低相关（aOR=0.54，95%CI=0.30-0.96）。
较高浓度的血液铅与 2-15 岁儿童哮喘的可能性增加相关。
