Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China.
Sci Rep. 2024 Sep 3;14(1):20457. doi: 10.1038/s41598-024-70250-8.
Asthma start, development, and exacerbation have all been linked in numerous studies to exposure to a variety of metal elements. However, there is still a dearth of epidemiological data linking heavy metal exposure to death in asthmatics. The investigation included 2432 eligible adults with asthma. The study examined the possible correlation between blood heavy metal levels and all-cause mortality. This was done by utilizing Cox proportional hazards models, restricted cubic spline (RCS), threshold effect models, and CoxBoost models. Subgroup analyses were conducted to investigate the associations between blood metal levels and all-cause mortality among distinct asthmatic populations. An inverse association was found between blood selenium and all-cause mortality in asthmatics, while blood manganese showed a positive association with all-cause mortality. However, there were no significant connections found between blood lead, cadmium, mercury, and all-cause mortality via multivariate Cox proportional hazard models. In model 3, after accounting for all factors, all-cause mortality dropped by 10% for every additional 10 units of blood selenium (μg/L) and increased by 6% for every additional unit of blood manganese (μg/L). The RCS and threshold effect model found a U-shaped correlation between blood selenium, blood manganese, and all-cause mortality. The lowest all-cause mortality among asthmatics was observed when blood selenium and manganese were 188.66 μg/L and 8.47 μg/L, respectively. Our investigation found a U-shaped correlation between blood selenium levels, blood manganese levels, and all-cause mortality in asthmatic populations. Optimizing dietary selenium intake and effectively managing manganese exposure could potentially improve the prognosis of asthma.
哮喘的发生、发展和恶化都与多种金属元素的暴露有关。然而，目前仍缺乏将重金属暴露与哮喘患者死亡联系起来的流行病学数据。该研究纳入了 2432 名符合条件的成年哮喘患者。研究探讨了血液重金属水平与全因死亡率之间的可能相关性。这是通过 Cox 比例风险模型、限制立方样条（RCS）、阈值效应模型和 CoxBoost 模型来实现的。进行了亚组分析，以研究不同哮喘人群中血液金属水平与全因死亡率之间的关联。结果表明，哮喘患者血液硒水平与全因死亡率呈负相关，而血液锰水平与全因死亡率呈正相关。然而，多变量 Cox 比例风险模型并未发现血液铅、镉、汞与全因死亡率之间存在显著关联。在模型 3 中，在考虑了所有因素后，血液硒每增加 10 个单位（μg/L），全因死亡率降低 10%，血液锰每增加 1 个单位（μg/L），全因死亡率增加 6%。RCS 和阈值效应模型发现血液硒、血液锰与全因死亡率之间呈 U 形相关。当血液硒和锰分别为 188.66μg/L 和 8.47μg/L 时，哮喘患者的全因死亡率最低。本研究发现哮喘人群中血液硒水平、血液锰水平与全因死亡率之间呈 U 形相关。优化膳食硒摄入和有效管理锰暴露可能改善哮喘的预后。
