PARP-1 在响应 DNA 损伤时的来来往往。
The comings and goings of PARP-1 in response to DNA damage.
机构信息
Université de Montréal, Department of Biochemistry and Molecular Medicine, 2900 Boulevard Edouard-Montpetit, Roger-Gaudry Pavillon, D-347, Montréal, Qc H3T 1J4 Canada.
出版信息
DNA Repair (Amst). 2018 Nov;71:177-182. doi: 10.1016/j.dnarep.2018.08.022. Epub 2018 Aug 23.
Abstract
Poly(ADP-ribose) polymerase (PARP) enzymes are broadly involved in the cellular response to DNA damage. PARP-1 is the chief human PARP enzyme involved in the DNA damage response, acting as a first responder that detects DNA strand breaks, and contributes to repair pathway choice and the efficiency of repair through modulation of chromatin structure and through interaction with and modification of a multitude of DNA repair factors. This perspective summarizes our knowledge of PARP-1 involvement in DNA repair pathways, and highlights recent structural and functional data regarding the activation of PARP-1 upon detecting DNA damage, and the release and trapping of PARP-1 at sites of DNA damage.
摘要
聚（ADP-核糖）聚合酶（PARP）酶广泛参与细胞对 DNA 损伤的反应。PARP-1 是参与 DNA 损伤反应的主要人类 PARP 酶，作为第一个检测 DNA 链断裂的反应蛋白，通过调节染色质结构以及与和修饰众多 DNA 修复因子来影响修复途径的选择和修复效率。本文综述了我们对 PARP-1 参与 DNA 修复途径的认识，并强调了最近关于 PARP-1 在检测 DNA 损伤时的激活以及在 DNA 损伤部位的释放和捕获的结构和功能数据。
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