Queensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Health and Food Sciences Precinct, Coopers Plains, QLD 4108, Australia.
Department of Agriculture and Fisheries, Queensland Government, Health and Food Sciences Precinct, Coopers Plains, QLD 4108, Australia.
Toxins (Basel). 2018 Sep 3;10(9):356. doi: 10.3390/toxins10090356.
Indospicine, a hepatotoxic arginine analog, occurs in leguminous plants of the genus and accumulates in the tissues of grazing animals that consume these plants. Furthermore, indospicine has caused toxicity in dogs following consumption of indospicine-contaminated meat; however, the potential impact on human health is unknown. The present study was designed to determine the effect of simulated human gastrointestinal digestion on the release and degradation of indospicine from contaminated camel meat following microwave cooking. Results showed no significant ( > 0.05) indospicine degradation during cooking or in vitro digestion. However, approximately 70% indospicine was released from the meat matrix into the liquid digesta during the gastric phase (in the presence of pepsin) and increased to >90% in the intestinal phase (with pancreatic enzymes). Following human consumption of contaminated meat, this soluble and more bioaccessible fraction of intact indospicine could be readily available for absorption by the small intestine, potentially circulating indospicine throughout the human body to tissues where it could accumulate and cause detrimental toxic effects.
相思豆毒素是一种有毒的精氨酸类似物，存在于豆科植物中，会在食用这些植物的放牧动物的组织中积累。此外，相思豆毒素污染的肉被狗食用后，会导致狗中毒；然而，其对人类健康的潜在影响尚不清楚。本研究旨在确定模拟人体胃肠道消化对微波烹饪污染骆驼肉中相思豆毒素释放和降解的影响。结果表明，烹饪或体外消化过程中，相思豆毒素没有明显降解（>0.05）。然而，在胃期（存在胃蛋白酶时），约 70%的相思豆毒素从肉基质中释放到液体消化物中，并在肠期（有胰腺酶时）增加到>90%。人食用污染的肉后，完整的相思豆毒素中这种可溶性和更易生物利用的部分可以很容易被小肠吸收，潜在地使相思豆毒素在人体全身循环，到达它可以积累并造成有害毒性作用的组织。
