Unit of Psychiatry,Faculty of Health Sciences,University of Macau,Macao SAR,China.
Department of Neurosurgery,The Affiliated Hospital of Southwest Medical University,Luzhou,China.
Psychol Med. 2019 Jul;49(10):1691-1704. doi: 10.1017/S0033291718002301. Epub 2018 Sep 4.
Suicide attempt (SA), which is one of the strongest predictors of completed suicide, is common in major depressive disorder (MDD) but its prevalence across epidemiological studies has been mixed. The aim of this comprehensive meta-analysis was to examine the pooled prevalence of SA in individuals with MDD.
A systematic literature search was conducted in PubMed, Embase, PsycINFO, Web of Science and Cochrane Library from their commencement date until 27 December 2017. Original studies containing data on prevalence of SA in individuals with MDD were analyzed.
In all, 65 studies with a total of 27 340 individuals with MDD were included. Using the random effects model, the pooled lifetime prevalence of SA was 31% [95% confidence interval (CI) 27-34%], 1-year prevalence was 8% (95% CI 3-14%) and 1-month prevalence was 24% (95% CI 15-34%). Subgroup analyses revealed that the lifetime prevalence of SA was significantly associated with the patient setting, study region and income level, while the 1-month prevalence of SA was associated with only the patient setting.
This meta-analysis confirmed that SA was common in individuals with MDD across the world. Careful screening and appropriate interventions should be implemented for SA in the MDD population.
自杀未遂（SA）是自杀的最强预测因素之一，在重度抑郁症（MDD）中很常见，但在流行病学研究中的发生率存在差异。本综合荟萃分析的目的是评估 MDD 患者中 SA 的总发生率。
我们在 PubMed、Embase、PsycINFO、Web of Science 和 Cochrane Library 中进行了系统的文献检索，检索时间截至 2017 年 12 月 27 日。分析了包含 MDD 患者 SA 发生率数据的原始研究。
共纳入了 65 项研究，总计 27340 名 MDD 患者。采用随机效应模型，SA 的终生发生率为 31%（95%CI：27-34%），1 年发生率为 8%（95%CI：3-14%），1 个月发生率为 24%（95%CI：15-34%）。亚组分析显示，SA 的终生发生率与患者背景、研究地区和收入水平显著相关，而 1 个月发生率仅与患者背景相关。
本荟萃分析证实，SA 在全球范围内的 MDD 患者中较为常见。在 MDD 人群中，应仔细筛查并实施适当的干预措施。
