Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China.
Guangdong Mental Health Center, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangdong Province, China.
J Affect Disord. 2018 Jan 1;225:32-39. doi: 10.1016/j.jad.2017.07.043. Epub 2017 Jul 29.
Suicidal behaviors are common in major depressive disorder (MDD) and contribute significantly to premature death. The objective of this meta-analysis is to estimate the pooled prevalence of suicidal behaviors in patients with MDD in China.
The relevant databases in English (PubMed, Embase, PsycINFO and Cochrane Library) and Chinese (Chinese National Knowledge Infrastructure, Wanfang and Chinese Biological Medical Literature) were systematically and independently searched from their inceptions until January 23, 2017. Original studies that reported the prevalence of suicidal behaviors including suicidal ideation (SI), suicide plan (SP), suicide attempt (SA) and completed suicide (CS) were included.
Thirty three articles that met the inclusion criteria were analyzed. The pooled lifetime prevalence of SI, SP and SA were 53.1% (95% CI: 42.4-63.4%), 17.5% (95% CI: 5.8-42.3%) and 23.7% (95% CI: 19.9-28.0%), respectively. One-month prevalence of SI and SA were 27.7% (95% CI: 15.4-44.5%) and 20.3% (95% CI: 12.1-32.2%), respectively. The pooled prevalence of SA during hospitalization and after onset of MDD were 17.3% (95% CI: 12.4-23.7%) and 42.1% (95% CI: 26.1-60.0%), respectively. Subgroup analyses revealed significant differences in both lifetime prevalence of SI and SA between genders, and between outpatients and inpatients with MDD.
Suicidal behaviors are common in MDD patients in China. Regular screening and effective intervention for suicidal behavior in MDD patients are warranted.
自杀行为在重度抑郁症（MDD）中很常见，是导致早逝的主要原因。本研究旨在评估中国 MDD 患者自杀行为的总发生率。
我们系统地检索了英文数据库（PubMed、Embase、PsycINFO 和 Cochrane Library）和中文数据库（中国知网、万方和中国生物医学文献），检索时间截至 2017 年 1 月 23 日。纳入报告自杀意念（SI）、自杀计划（SP）、自杀企图（SA）和自杀死亡（CS）发生率的研究。
共纳入 33 项研究。终生 SI、SP 和 SA 的发生率分别为 53.1%（95%CI：42.4-63.4%）、17.5%（95%CI：5.8-42.3%）和 23.7%（95%CI：19.9-28.0%）。1 个月时 SI 和 SA 的发生率分别为 27.7%（95%CI：15.4-44.5%）和 20.3%（95%CI：12.1-32.2%）。住院期间和 MDD 发病后 SA 的发生率分别为 17.3%（95%CI：12.4-23.7%）和 42.1%（95%CI：26.1-60.0%）。亚组分析显示，MDD 患者中 SI 和 SA 的终生发生率在性别间、门诊和住院患者间存在显著差异。
中国 MDD 患者自杀行为较为常见，应对 MDD 患者进行自杀行为的常规筛查和有效干预。
