University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Roslin, UK.
Transbound Emerg Dis. 2019 Jan;66(1):250-258. doi: 10.1111/tbed.13010. Epub 2018 Nov 1.
Mycobacterium bovis is a re-emerging zoonosis; it was diagnosed in five Abyssinian cats in a breeding cattery in Italy. The infection entered the cattery with an imported kitten (cat A); it had a suspected bite wound on its leg that had been treated at a veterinary clinic in Kiev, Ukraine, which is probably where it became infected with M. bovis. When the kitten arrived in Italy, there were four cats in the cattery; an adult female, her two kittens and a kitten imported from Russia. These were all healthy, and had no outdoor access. All five cats developed tuberculous interstitial pneumonia; in cat A this occurred 6 weeks after importation, the others were diagnosed 4-6 weeks later. Three cats were euthanised with deteriorating pneumonia while two cats remained clinically well on antibiotic therapy (marbofloxacin, doxycycline and azithromycin). The latter cases were euthanised after 5 weeks, as required by Italian law once M. bovis infection was suspected. Changes consistent with tuberculosis on gross post-mortem examination included mesenteric and mediastinal lymphadenopathy, splenomegaly and hepatomegaly, and the presence of disseminated focal white lesions on the cut surface of the spleen, liver and lungs. Visible acid-fast bacteria (cats A, B and C) were confirmed as Mycobacterium tuberculosis complex by PCR (cats A, B, C, D and E), refined to M. bovis (cats A, B and D), spoligotype SB0950 (cats A and D).
牛分枝杆菌是一种重新出现的人畜共患病；在意大利的一个繁殖场中，有五只阿比西尼亚猫被诊断出患有该病。该感染是随一只进口小猫（A 猫）进入繁殖场的；它的腿部有一处疑似被咬伤的伤口，曾在乌克兰基辅的一家兽医诊所接受过治疗，很可能就是在那里感染了牛分枝杆菌。当小猫抵达意大利时，繁殖场里有四只猫；一只成年母猫、她的两只小猫和一只从俄罗斯进口的小猫。这些猫都很健康，没有户外活动。这五只猫都患上了结核性间质性肺炎；A 猫在进口后 6 周发病，其他猫则在 4-6 周后被诊断出患病。三只猫因肺炎恶化而被实施安乐死，而两只猫在接受抗生素治疗（马波沙星、多西环素和阿奇霉素）后仍保持临床健康。由于怀疑感染了牛分枝杆菌，按照意大利法律的要求，后两例在 5 周后被实施安乐死。大体剖检时与结核病一致的变化包括肠系膜和纵隔淋巴结病、脾肿大和肝肿大，以及脾脏、肝脏和肺部切面散布有局灶性白色病变。可见的抗酸杆菌（A 猫、B 猫和 C 猫）通过 PCR 被确认为结核分枝杆菌复合群（A 猫、B 猫、C 猫、D 猫和 E 猫），进一步细化为牛分枝杆菌（A 猫、B 猫和 D 猫）， spoligotype SB0950（A 猫和 D 猫）。
