Graves J M, Colwell J A, Nair R M, Sarji K E
Clin Endocrinol (Oxf). 1977 Jun;6(6):437-42. doi: 10.1111/j.1365-2265.1977.tb03326.x.
We have previously noted increased platelet aggregation and high von Willebrand factor activity in patients with chemical diabetes. In this paper we have studied platelet aggregation, plasma glucose, insulin, free fatty acids, growth hormone, and von Willebrand factor activity during the glucose tolerance test in six normal and six chemical diabetic subjects. The results suggest that von Willebrand factor activity is suppressed coincident with the rise of glucose and insulin and provide further evidence of hormonal and metabolic control of levels of von Willebrand factor activity.
我们之前已经注意到，化学性糖尿病患者存在血小板聚集增加和血管性血友病因子活性升高的情况。在本文中，我们研究了6名正常人和6名化学性糖尿病患者在葡萄糖耐量试验期间的血小板聚集、血糖、胰岛素、游离脂肪酸、生长激素及血管性血友病因子活性。结果表明，血管性血友病因子活性随着葡萄糖和胰岛素水平的升高而受到抑制，这为血管性血友病因子活性水平的激素及代谢调控提供了进一步证据。
