Lufkin E G, Fass D N, O'Fallon W M, Bowie E J
Metabolism. 1979 Jan;28(1):63-6. doi: 10.1016/0026-0495(79)90169-0.
Abnormal platelet function may play a role in the genesis of vascular complications in diabetes mellitus. We measured plasma levels of ristocetin-Willebrand factor and factor VIII antigen in 75 subjects and also measured aggregation-enhancing factor in subsets. We found increased levels of ristocetin-Willebrand factor in all groups of diabetics studied, even in mild diabetics free of vascular disease. Factor VIII antigen was increased only in diabetics with vascular disease. We could not find an aggregation-enhancing factor in any group.
血小板功能异常可能在糖尿病血管并发症的发生中起作用。我们检测了75名受试者血浆中瑞斯托霉素-血管性血友病因子和因子VIII抗原水平，并对部分受试者检测了聚集增强因子。我们发现，在所有研究的糖尿病患者组中，瑞斯托霉素-血管性血友病因子水平均升高，即使是无血管疾病的轻度糖尿病患者也是如此。因子VIII抗原仅在患有血管疾病的糖尿病患者中升高。我们在任何组中均未发现聚集增强因子。
