多中心性网状组织细胞增生症：一例报告。
Multicentric reticulohistiocytosis: a case report.
作者信息
Farokhi Azadèh, van Vugt Richard M, Hoekzema Rick, Nurmohamed Michael T
机构信息
VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Rheumatology Department, VUMC Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
出版信息
BMC Res Notes. 2018 Sep 4;11(1):647. doi: 10.1186/s13104-018-3753-3.
BACKGROUND
Multicentric reticulohistiocytosis is a rare form of non-langerhans cell histiocytosis presenting with skin changes and erosive arthritis. Infiltration of histiocytes and multinucleated giant cells are typical histological findings and confirm the diagnosis.
CASE PRESENTATION
This case report describes a newly diagnosed case of multicentric reticulohistiocytosis in a healthy 26-year-old female originally from the Philippines. Eruption of papules and nodules on the hands and pain in multiple joints were the main complaints at the initial presentation. Radiographical findings of erosions in the small hand and feet joints were impressive. Initial histological findings did not match the clinical image, although later the clinical diagnosis was supported by histological findings in additional biopsies.
CONCLUSIONS
Although initial histological findings did not match the clinical image, additional biopsies were valuable to confirm the diagnosis.
背景
多中心网状组织细胞增生症是一种罕见的非朗格汉斯细胞组织细胞增生症，表现为皮肤改变和侵蚀性关节炎。组织细胞和多核巨细胞浸润是典型的组织学表现，可确诊该病。
病例报告
本病例报告描述了一名新诊断为多中心网状组织细胞增生症的26岁健康菲律宾女性。最初就诊时的主要症状是手部丘疹和结节疹以及多关节疼痛。手部和足部小关节侵蚀的影像学表现令人印象深刻。最初的组织学表现与临床影像不相符，不过后来额外活检的组织学结果支持了临床诊断。
结论
尽管最初的组织学表现与临床影像不相符，但额外活检对于确诊很有价值。
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