代谢综合征中胆固醇相关基因的遗传学：当前证据综述
Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence.
作者信息
Wong Sok Kuan, Ramli Fitri Fareez, Ali Adli, Ibrahim Nurul 'Izzah
机构信息
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras 56000, Kuala Lumpur, Malaysia.
Clinical Psychopharmacology Research Unit, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK.
出版信息
Biomedicines. 2022 Dec 13;10(12):3239. doi: 10.3390/biomedicines10123239.
Metabolic syndrome (MetS) refers to a cluster of metabolic dysregulations, which include insulin resistance, obesity, atherogenic dyslipidemia and hypertension. The complex pathogenesis of MetS encompasses the interplay between environmental and genetic factors. Environmental factors such as excessive nutrients and sedentary lifestyle are modifiable and could be improved by lifestyle modification. However, genetic susceptibility to MetS, a non-modifiable factor, has attracted the attention of researchers, which could act as the basis for future diagnosis, prognosis, and therapy for MetS. Several cholesterol-related genes associated with each characteristic of MetS have been identified, such as apolipoprotein, lipoprotein lipase (LPL), cholesteryl ester transfer protein (CETP) and adiponectin. This review aims to summarize the genetic information of cholesterol-related genes in MetS, which may potentially serve as biomarkers for early prevention and management of MetS.
代谢综合征（MetS）是指一系列代谢失调，包括胰岛素抵抗、肥胖、致动脉粥样硬化血脂异常和高血压。MetS复杂的发病机制涉及环境因素与遗传因素之间的相互作用。过量营养和久坐不动的生活方式等环境因素是可以改变的，通过改变生活方式可以得到改善。然而，MetS的遗传易感性这一不可改变的因素已引起研究人员的关注，它可作为未来MetS诊断、预后和治疗的基础。已经鉴定出了几个与MetS各特征相关的胆固醇相关基因，如载脂蛋白、脂蛋白脂肪酶（LPL）、胆固醇酯转运蛋白（CETP）和脂联素。本综述旨在总结MetS中胆固醇相关基因的遗传信息，这些信息可能潜在地作为MetS早期预防和管理的生物标志物。
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