Dept Physiological Sciences, Science Faculty, Stellenbosch University, Stellenbosch, South Africa.
Food Funct. 2018 Oct 17;9(10):5041-5058. doi: 10.1039/c8fo01010b.
Increasing consumer bias toward natural products and the considerable wealth of indigenous knowledge has precipitated an upturn in market-driven research into potentially beneficial medicinal plants. In this context, Aspalathus linearis (Rooibos) has been identified to be a promising candidate which may impact cardiovascular disease (CVD), which is one of the most widely studied chronic diseases of modern times. Despite these efforts, ischemic heart disease remains the number one cause of mortality globally. Apart from genetic predisposition and other aetiological mechanisms specific to particular types of CVD, co-factors from interlinked systems contribute significantly to disease development and the severity of its clinical manifestation. The bioactivity of Rooibos is directed towards multiple therapeutic targets. Experimental data to date include antioxidant, anti-inflammatory and anti-diabetic effects, as well as modulatory effects in terms of the immune system, adrenal steroidogenesis and lipid metabolism. This review integrates relevant literature on the therapeutic potential of Rooibos in the context of CVD, which is currently the most common of non-communicable diseases. The therapeutic value of whole plant extracts versus isolated active ingredients are addressed, together with the potential for overdose or herb-drug interaction. The body of research undertaken to date clearly underlines the benefits of Rooibos as both preventative and complementary therapeutic functional food in the context of CVD.
消费者对天然产品的偏好不断增加，本土知识也相当丰富，这促使市场驱动型研究对潜在有益的药用植物进行了研究。在这种情况下，Aspalathus linearis（南非路易波士茶）已被确定为一种很有前途的候选药物，可能对心血管疾病（CVD）产生影响，而 CVD 是现代研究最多的慢性疾病之一。尽管进行了这些努力，缺血性心脏病仍然是全球头号死因。除了遗传易感性和特定类型 CVD 的其他病因机制外，相互关联的系统中的共同因素对疾病的发展及其临床表现的严重程度有重大影响。南非路易波士茶的生物活性针对多个治疗靶点。迄今为止的实验数据包括抗氧化、抗炎和抗糖尿病作用，以及对免疫系统、肾上腺类固醇生成和脂质代谢的调节作用。本综述综合了关于南非路易波士茶在 CVD 方面的治疗潜力的相关文献，CVD 是目前最常见的非传染性疾病。本文讨论了全植物提取物与分离的活性成分的治疗价值，以及过量或草药-药物相互作用的可能性。迄今为止进行的研究充分强调了南非路易波士茶作为预防和补充治疗功能食品在 CVD 中的益处。
