Wieler H, Herzog H, Patton D D, Schmid A, Rota E, Feinendegen L E
Med Prog Technol. 1986;11(2):73-106.
Positron Emission Tomography (PET) has evolved in the last years into a powerful research technique for the study of the physiology and pathophysiology of the human brain in vivo. These procedures now need no longer be viewed only as research studies. They are ready to be applied clinically on a wide scale. This article will give a short overview of the technical and methodological background and outline the clinical research applications by using the most developed tracers in the field: glucose and its analogs, oxygen, fatty acids, various perfusion markers and receptors, all labelled with positron emitting isotopes. They allow the quantitative measurement of local tissue functions in an essentially non-invasive way.
正电子发射断层扫描（PET）在过去几年中已发展成为一种强大的研究技术，用于在体研究人类大脑的生理学和病理生理学。这些检查现在不再仅仅被视为研究性检查。它们已准备好在临床上广泛应用。本文将简要概述其技术和方法学背景，并通过使用该领域最成熟的示踪剂：葡萄糖及其类似物、氧气、脂肪酸、各种灌注标记物和受体（均用发射正电子的同位素标记）来概述临床研究应用。它们能够以基本无创的方式对局部组织功能进行定量测量。
