Mora-Muñoz Laura, Guerrero-Naranjo Alejandro, Rodríguez-Jimenez Elisa Angélica, Mastronardi Claudio Alberto, Velez-van-Meerbeke Alberto
Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Cra 24 No 63C-69, Bogotá, Colombia.
BMC Neurosci. 2018 Sep 5;19(1):51. doi: 10.1186/s12868-018-0453-9.
Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. The aim of this study was to review the association between leptin and cerebral neuronal function, in particular its anticonvulsant or convulsant effects and the possible therapeutic role for treating epilepsy. For this purpose, the databases Pubmed, Science Direct, Elsevier, ResearchGate and Scielo were searched to identify experimental studies, reviews and systematic review articles, published in English, Spanish or Portuguese. Experimental studies and the presence of leptin receptors in nervous system sites other than the hypothalamus suggest an influence on higher brain functions. Indeed several animal studies have demonstrated a role of these channels in epileptiform activity as both anticonvulsive and convulsive effects have been found. The reason for these discrepancies is unclear but provides clear evidence of a potential role of leptin and leptin therapy in epileptiform activity. The association between leptin and brain function demonstrates the importance of peripheral metabolic hormones on central nervous system and opens a new way for the development of novel therapeutic interventions in diseases like epilepsy. Nevertheless further investigations are important to clarify the dynamics and diverse actions of leptin on excitatory regulation in the brain.
脂肪组织是一个对身体有不同影响的动态器官。其中许多影响是由瘦素介导的，瘦素是一种在进食和能量代谢调节中起重要作用的激素。它作为神经元兴奋性活动和高级脑功能的介质发挥着重要作用。本研究的目的是综述瘦素与脑神经元功能之间的关联，特别是其抗惊厥或惊厥作用以及在治疗癫痫方面可能的治疗作用。为此，检索了PubMed、Science Direct、Elsevier、ResearchGate和Scielo数据库，以识别用英文、西班牙文或葡萄牙文发表的实验研究、综述和系统评价文章。实验研究以及下丘脑以外的神经系统部位存在瘦素受体表明其对高级脑功能有影响。事实上，多项动物研究已证明这些通道在癫痫样活动中发挥作用，因为已发现其具有抗惊厥和惊厥作用。这些差异的原因尚不清楚，但为瘦素和瘦素疗法在癫痫样活动中的潜在作用提供了明确证据。瘦素与脑功能之间的关联表明外周代谢激素对中枢神经系统的重要性，并为癫痫等疾病开发新型治疗干预措施开辟了一条新途径。然而，进一步的研究对于阐明瘦素对大脑兴奋性调节的动态和多样作用很重要。
