Tukacs Monika
Monika Tukacs is Clinical Nurse III, Cardiothoracic Intensive Care Unit, Columbia University Irving Medical Center and New York-Presbyterian Hospital; and Academic Research Fellow at the Columbia University School of Nursing, 177 Fort Washington Ave, New York, NY 10032 (
AACN Adv Crit Care. 2018 Fall;29(3):246-258. doi: 10.4037/aacnacc2018439.
Extracorporeal membrane oxygenation is a rapidly emerging treatment for respiratory or cardiac failure and is used as a bridge to recovery, transplant, or destination therapy. Adult patients receiving extracorporeal membrane oxygenation also receive significant amounts of pharmacotherapy. Although the body of literature on extra-corporeal membrane oxygenation in general is extensive, only a few publications focus on pharmacokinetic changes related to extracorporeal membrane oxygenation in adults. Understanding pharmacokinetics in adult patients receiving extracorporeal membrane oxygenation is important to correctly select and dose medications in this patient population. This article reviews published studies of the effects of extracorporeal membrane oxygenation on pharmacokinetics in adults.
体外膜肺氧合是一种迅速兴起的用于治疗呼吸衰竭或心力衰竭的疗法，用作恢复、移植或目标治疗的桥梁。接受体外膜肺氧合的成年患者也会接受大量药物治疗。尽管关于体外膜肺氧合的文献总体上很丰富，但只有少数出版物关注与成年患者体外膜肺氧合相关的药代动力学变化。了解接受体外膜肺氧合的成年患者的药代动力学对于在该患者群体中正确选择药物和确定给药剂量很重要。本文综述了已发表的关于体外膜肺氧合对成年人药代动力学影响的研究。
