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赋予病毒DNA复制细胞特异性顺式优势的多瘤病毒突变。

Polyomavirus mutation that confers a cell-specific cis advantage for viral DNA replication.

作者信息

De Simone V, La Mantia G, Lania L, Amati P

出版信息

Mol Cell Biol. 1985 Aug;5(8):2142-6. doi: 10.1128/mcb.5.8.2142-2146.1985.

DOI:10.1128/mcb.5.8.2142-2146.1985
PMID:3018552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC366932/
Abstract

The structural and biological properties of a polyomavirus mutant selected in Friend erythroleukemic cells were investigated. The growth efficiency of this mutant (PyFL78) was compared with that of the parental PyA2 strain by a growth competition assay in Friend erythroleukemic and 3T3 (or 3T6) cell lines. The results reveal that PyFL78 displays a cis-acting growth advantage over the PyA2 parental strain in Friend erythroleukemic cells but not in 3T3 or 3T6 cells. This cell-specific cis advantage is shown to be due to modifications within the polyomavirus noncoding regulatory region.

摘要

对在Friend红白血病细胞中筛选出的一种多瘤病毒突变体的结构和生物学特性进行了研究。通过在Friend红白血病细胞系和3T3（或3T6）细胞系中进行生长竞争试验，比较了该突变体（PyFL78）与亲本PyA2菌株的生长效率。结果表明，PyFL78在Friend红白血病细胞中相对于亲本PyA2菌株表现出顺式作用的生长优势，但在3T3或3T6细胞中则没有。这种细胞特异性的顺式优势被证明是由于多瘤病毒非编码调控区域内的修饰所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c0/366932/bab58d3d42d2/molcellb00104-0345-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c0/366932/4f1c740198d8/molcellb00104-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c0/366932/bab58d3d42d2/molcellb00104-0345-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c0/366932/4f1c740198d8/molcellb00104-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69c0/366932/bab58d3d42d2/molcellb00104-0345-a.jpg

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