DNA 病毒的 RNA 表观转录组。
The RNA Epitranscriptome of DNA Viruses.
机构信息
Department of Systems Biology, City of Hope, Monrovia, California, USA.
UPMC Hillman Cancer Center, Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
出版信息
J Virol. 2018 Oct 29;92(22). doi: 10.1128/JVI.00696-18. Print 2018 Nov 15.
Abstract
RNA modifications have generated much interest in the virology field, as recent works have shown that many viruses harbor these marks and modify cellular marks. The most abundant mRNA modification in eukaryotic cells, -methyladenosine (mA), has been examined extensively at the genome-wide scale in both cellular and viral contexts. This Gem discusses the role of mA in gene regulation and describes recent advancements in Kaposi's sarcoma-associated herpesvirus (KSHV) and simian virus 40 (SV40) research. We provide insights into future research related to mA in DNA viruses.
摘要
RNA 修饰在病毒学领域引起了广泛关注，因为最近的研究表明许多病毒都携带有这些修饰，并修饰细胞的修饰。在真核细胞中，最丰富的 mRNA 修饰是 N6-甲基腺嘌呤（mA），它在细胞和病毒环境中都在全基因组范围内进行了广泛的研究。本文讨论了 mA 在基因调控中的作用，并描述了卡波济肉瘤相关疱疹病毒（KSHV）和猿猴病毒 40（SV40）研究的最新进展。我们提供了有关 DNA 病毒中 mA 的未来研究的见解。
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