Department of Medical Nursing, Weifang Medical University , Wei Fang , China.
Front Aging Neurosci. 2015 Mar 12;7:22. doi: 10.3389/fnagi.2015.00022. eCollection 2015.
The aim was to evaluate the mismatch negativity (MMN) component, a correlate of the automatic detection of changes in the acoustic environment, in healthy adults, and adults with amnestic mild cognitive impairment (aMCI). Forty-three aMCI subjects and 43 healthy Chinese older adults were arranged into experimental group and control group, respectively. Their MMN amplitude and latency were measured at the FZ, FCZ, and CZ electrode sites under a passive auditory oddball task. The results showed that the latencies obtained from the FZ, FCZ, and CZ electrode sites were significantly longer in the aMCI adults than in the control adults (P < 0.01) while there were no significant differences in MMN amplitude between two groups (P > 0.05). The MMN latency was found to be a sensitive and specific biomarker of aMCI.
目的是评估失匹配负波（MMN）成分，这是对听觉环境变化自动检测的相关指标，在健康成年人和遗忘型轻度认知障碍（aMCI）成年人中进行评估。将 43 名 aMCI 受试者和 43 名健康中国老年人分别安排到实验组和对照组。在被动听觉Oddball 任务下，在 FZ、FCZ 和 CZ 电极部位测量他们的 MMN 振幅和潜伏期。结果表明，aMCI 成年人在 FZ、FCZ 和 CZ 电极部位获得的潜伏期明显长于对照组成年人（P<0.01），而两组之间的 MMN 振幅没有显著差异（P>0.05）。发现 MMN 潜伏期是 aMCI 的一种敏感和特异的生物标志物。
