Zhang Xiufeng, Zheng Hecheng, Liu Chengjing, Guo Jun, Wu Jian, Hu Liping, Nie Shengjie
School of Forensic Medicine, Kunming Medical University, Kunming City, Yunnan Province, People's Republic of China.
Chuxiong Public Security Bureau, Chuxiong City, Yunnan Province, People's Republic of China.
Int J Legal Med. 2019 Jan;133(1):103-104. doi: 10.1007/s00414-018-1930-5. Epub 2018 Sep 5.
The genetic polymorphisms of 15 autosomal short tandem repeat (STR) loci included in the AmpFlSTR®Sinofiler™ kit were evaluated from 508 unrelated healthy individuals of the Lisu ethnic minority living in Chuxiong Yi Autonomous Prefecture, Yunnan province, southwest of China. Fourteen of the 15 loci reached the Hardy-Weinberg equilibrium after Bonferroni correction. These loci were examined to determine allele frequencies and forensic statistical parameters. The genetic relationship between the Lisu population and other Chinese populations were also estimated. The combined discrimination power and probability of excluding paternity of the 15 STR loci were 0.999 999 999 999 999 999 654 and 0.999 998 882, respectively. These results suggest that the 15 STR loci are highly polymorphic, which is suitable for forensic personal identification and paternity testing.
对来自中国西南部云南省楚雄彝族自治州的508名傈僳族无关健康个体，评估了AmpFlSTR®Sinofiler™试剂盒中包含的15个常染色体短串联重复序列（STR）基因座的遗传多态性。15个基因座中的14个在Bonferroni校正后达到Hardy-Weinberg平衡。检测这些基因座以确定等位基因频率和法医统计参数。还估计了傈僳族群体与其他中国群体之间的遗传关系。15个STR基因座的联合鉴别力和排除父权概率分别为0.999 999 999 999 999 999 654和0.999 998 882。这些结果表明，15个STR基因座具有高度多态性，适用于法医个人识别和亲子鉴定。
