School of Forensic Medicine, Kunming Medical University, Kunming, China; Judicial Expertise Center, Kunming Medical University, Kunming, China.
School of Forensic Medicine, Kunming Medical University, Kunming, China.
Leg Med (Tokyo). 2022 May;56:102044. doi: 10.1016/j.legalmed.2022.102044. Epub 2022 Feb 12.
Allele frequency distributions and statistical forensic parameters of 19 autosomal STR loci in a sample of 535 unrelated healthy Hui individuals from Yunnan province were estimated. A total of 236 alleles at these loci were identified and their corresponding allele frequencies ranged from 0.000935 to 0.527103. Penta E is the most informative in Hui population, whereas TPOX showed the lowest. All of the STR loci reached the Hardy-Weinberg equilibrium after Bonferroni correction. The combined discrimination power and probability of excluding paternity of the 19 STR loci were 0.999 999 999 999 999 999 999 984 47 16 and 0.999 999 988, respectively. Furthermore, the genetic relationship between the Yunnan Hui population and other 8 different Hui groups or 25 previously investigated groups residing in other areas of China were also estimated based on pairwise genetic distance. These results suggest that the 19 STR loci are highly polymorphic, which is suitable for forensic personal identification and paternity testing.
对来自云南省的 535 名无亲缘关系的健康回族个体样本中的 19 个常染色体 STR 基因座的等位基因频率分布和统计法庭参数进行了估计。在这些基因座中共鉴定出 236 个等位基因,其对应的等位基因频率范围为 0.000935 至 0.527103。在回族人群中,Penta E 是最具信息量的,而 TPOX 则显示出最低的信息量。经 Bonferroni 校正后,所有 STR 基因座均达到 Hardy-Weinberg 平衡。19 个 STR 基因座的联合判别能力和排除亲子关系的概率分别为 0.999999999999999999999844716 和 0.99999999999999988。此外,还基于成对遗传距离估计了云南回族人群与其他 8 个不同回族群体或中国其他地区 25 个先前调查群体之间的遗传关系。这些结果表明,这 19 个 STR 基因座具有高度多态性,适用于法医个体识别和亲子鉴定。