Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, China.
Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Qingdao University, Qingdao, China.
Neurol Sci. 2018 Dec;39(12):2085-2089. doi: 10.1007/s10072-018-3543-7. Epub 2018 Sep 5.
A meta-analysis was performed to assess the association between the dopamine beta-hydroxylase (DBH) rs1611115 genetic polymorphism and Parkinson's disease (PD). A comprehensive search was conducted to identify all case-control or cohort studies. The fixed or random effect-pooled measure was selected on the basis of a homogeneity test among studies. Heterogeneity among studies was evaluated using the I. We performed sensitivity analyses to evaluate the robustness of the results. Publication bias was estimated using Egger's linear regression test. Five case-control studies corresponded to the inclusion criteria comprising 3926 patients and 3542 controls which were included in the present meta-analysis. Our meta-analysis showed no significant association between DBH rs1611115 genetic polymorphism and risk of PD in the codominant (REM, OR = 1.017, 95%CI = 0.854-1.210), dominant (REM, OR = 0.989, 95%CI = 0.826-1.185), and recessive (REM, OR = 1.007, 95%CI = 0.657-1.542) models. Moreover, in the subgroup analysis based on region (Asia and Europe), no significant associations were observed in Asia or Europe. This meta-analysis suggests that the DBH rs1611115 genetic polymorphism might not be associated with PD.
进行了一项荟萃分析，以评估多巴胺-β-羟化酶（DBH）rs1611115 基因多态性与帕金森病（PD）之间的关联。进行了全面搜索，以确定所有病例对照或队列研究。根据研究之间的同质性检验，选择固定或随机效应合并度量。使用 I 评估研究之间的异质性。我们进行敏感性分析以评估结果的稳健性。使用 Egger 的线性回归检验估计发表偏倚。符合纳入标准的五项病例对照研究共纳入 3926 名患者和 3542 名对照，纳入本荟萃分析。我们的荟萃分析表明，DBH rs1611115 基因多态性与 PD 的风险在显性模型（REMs，OR=1.017，95%CI=0.854-1.210）、隐性模型（REMs，OR=1.007，95%CI=0.657-1.542）和共显性模型（REMs，OR=1.017，95%CI=0.854-1.210）中无显著相关性。此外，基于区域（亚洲和欧洲）的亚组分析中，在亚洲或欧洲均未观察到显著相关性。本荟萃分析表明，DBH rs1611115 基因多态性可能与 PD 无关。
