Department of Chemistry , Drexel University , 32 South 32nd Street , Philadelphia , Pennsylvania 19104 , United States.
Org Lett. 2018 Sep 21;20(18):5910-5913. doi: 10.1021/acs.orglett.8b02574. Epub 2018 Sep 6.
Asmic addresses the long-standing challenge of alkylating isocyanides, providing access to isocyanides with diverse substitution patterns. The o-anisylsulfanyl group serves a critical dual role by facilitating deprotonation-alkylation and providing a latent nucleophilic site through an unusual arylsulfanyl-lithium exchange.
Asmic 解决了长期存在的烷基化异氰化物的挑战，为具有不同取代模式的异氰化物提供了途径。邻甲氧基苯硫基通过促进脱质子-烷基化和通过不寻常的芳基硫基-锂交换提供潜伏的亲核位点，起到了关键的双重作用。
