Liu Li-Na, Mao Yan-Mei, Zhao Chan-Na, Wang Hong, Yuan Fei-Fei, Li Xiao-Mei, Pan Hai-Feng
a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.
b Department of causes and interventions of chronic diseases , Anhui Province Key Laboratory of Major Autoimmune Diseases , Hefei , Anhui , China.
Immunol Invest. 2019 Feb;48(2):107-120. doi: 10.1080/08820139.2018.1510957. Epub 2018 Sep 6.
Currently published data regarding the potential role of osteoprotegerin (OPG), osteocalcin (OCN) and osteopontin (OPN) for the discrimination between rheumatoid arthritis (RA) and osteoarthritis (OA) are contradictory. To derive a more precise evaluation, a meta-analysis was performed.
Published literatures comparing plasma/serum OPG, OCN and OPN levels between RA group and OA controls were searched in PubMed, Embase and the Cochrane Library. The Newcastle-Ottawa Scale was used to assess the study quality. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by random-effect model analysis. Heterogeneity test was performed by the Q statistic and quantified using I.
Nine studies including 438 RA patients and 255 OA patients were finally incorporated in the meta-analysis after examining title, type, abstracts and full text. The results showed that RA patients had higher plasma/serum OPN (pooled SMD = -2.57, 95% CI = -4.72 to -0.41) levels when compared to OA patients. No significant difference in plasma/serum OPG (pooled SMD = -0.29, 95% CI = -1.07‒0.49) and OCN (pooled SMD = -0.09, 95% CI = -0.48‒0.31) levels were found between RA patients and OA patients. Subgroup analysis indicated that plasma/serum OPG levels had no significant differences between RA patients and OA patients in Europe and Asian.
Overall, there is no significant difference in circulating OPG and OCN levels between RA patients and OA patients. However, plasma/serum OPN level is significantly higher in RA patients compared with OA patients.
目前已发表的数据表明，骨保护素（OPG）、骨钙素（OCN）和骨桥蛋白（OPN）在区分类风湿关节炎（RA）和骨关节炎（OA）方面的潜在作用存在矛盾。为了得出更精确的评估结果，我们进行了一项荟萃分析。
在PubMed、Embase和Cochrane图书馆中检索已发表的比较RA组与OA对照组血浆/血清OPG、OCN和OPN水平的文献。采用纽卡斯尔-渥太华量表评估研究质量。通过随机效应模型分析计算合并标准平均差（SMD）及95%置信区间（CI）。采用Q统计量进行异质性检验，并使用I进行量化。
在对标题、类型、摘要和全文进行审查后，最终有9项研究纳入荟萃分析，其中包括438例RA患者和255例OA患者。结果显示，与OA患者相比，RA患者的血浆/血清OPN水平更高（合并SMD = -2.57，95%CI = -4.72至-0.41）。RA患者与OA患者的血浆/血清OPG（合并SMD = -0.29，95%CI = -1.07至0.49）和OCN（合并SMD = -0.09，95%CI = -0.48至0.31）水平无显著差异。亚组分析表明，欧洲和亚洲的RA患者与OA患者的血浆/血清OPG水平无显著差异。
总体而言，RA患者和OA患者的循环OPG和OCN水平无显著差异。然而，RA患者的血浆/血清OPN水平显著高于OA患者。
