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迈向脊髓灰质炎病毒遏制实施的进展 - 全球,2017-2018 年。

Progress Toward Poliovirus Containment Implementation - Worldwide, 2017-2018.

出版信息

MMWR Morb Mortal Wkly Rep. 2018 Sep 7;67(35):992-995. doi: 10.15585/mmwr.mm6735a5.

Abstract

Substantial progress has been made since the World Health Assembly (WHA) resolved to eradicate poliomyelitis in 1988 (1). Among the three wild poliovirus (WPV) types, type 2 (WPV2) was declared eradicated in 2015, and type 3 (WPV3) has not been reported since 2012 (1). In 2017 and 2018, only Afghanistan and Pakistan have reported WPV type 1 (WPV1) transmission (1). When global eradication of poliomyelitis is achieved, facilities retaining poliovirus materials need to minimize the risk for reintroduction of poliovirus into communities and reestablishment of transmission. Poliovirus containment includes biorisk management requirements for laboratories, vaccine production sites, and other facilities that retain polioviruses after eradication; the initial milestones are for containment of type 2 polioviruses (PV2s). At the 71st WHA in 2018, World Health Organization (WHO) Member States adopted a resolution urging acceleration of poliovirus containment activities globally, including establishment by the end of 2018 of national authorities for containment (NACs) to oversee poliovirus containment (2). This report summarizes containment progress since the previous report (3) and outlines remaining challenges. As of August 2018, 29 countries had designated 81 facilities to retain PV2 materials; 22 of these countries had established NACs. Although there has been substantial progress, intensification of containment measures is needed.

摘要

自 1988 年世界卫生大会(WHA)决议根除脊髓灰质炎以来,已经取得了实质性进展(1)。在三种野生脊髓灰质炎病毒(WPV)类型中,WPV2 已于 2015 年宣布根除,WPV3 自 2012 年以来未报告(1)。2017 年和 2018 年,只有阿富汗和巴基斯坦报告了 WPV1 传播(1)。当全球根除脊髓灰质炎时,保留脊髓灰质炎病毒材料的设施需要将病毒重新引入社区并重新建立传播的风险降到最低。脊髓灰质炎病毒的控制包括实验室、疫苗生产场所和其他在根除后保留脊髓灰质炎病毒的设施的生物风险管理要求;初始里程碑是控制 2 型脊髓灰质炎病毒(PV2s)。在 2018 年第 71 届 WHA 会议上,世界卫生组织(WHO)会员国通过了一项决议,敦促在全球范围内加速脊髓灰质炎病毒的控制活动,包括在 2018 年底前建立国家控制当局(NACs),以监督脊髓灰质炎病毒的控制(2)。本报告总结了自上次报告以来的控制进展情况,并概述了剩余的挑战(3)。截至 2018 年 8 月,已有 29 个国家指定了 81 个设施来保留 PV2 材料;其中 22 个国家已经建立了 NACs。尽管已经取得了实质性进展,但仍需要加强控制措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6eb/6132186/73933db6cb4b/mm6735a5-F.jpg

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