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2017年全球2型脊髓灰质炎病毒遏制进展

Progress Toward Containment of Poliovirus Type 2 - Worldwide, 2017.

作者信息

Previsani Nicoletta, Singh Harpal, St Pierre Jeanette, Boualam Liliane, Fournier-Caruana Jacqueline, Sutter Roland W, Zaffran Michel

出版信息

MMWR Morb Mortal Wkly Rep. 2017 Jun 23;66(24):649-652. doi: 10.15585/mmwr.mm6624a5.

Abstract

The Global Polio Eradication Initiative (GPEI) continues to make progress toward the eradication target. Only one of the three serotypes, wild poliovirus (WPV) type 1 (WPV1), is still circulating, and the numbers of cases and countries with endemic transmission are at record lows. With the certification of wild poliovirus type 2 (WPV2) eradication in 2015 and the global replacement of trivalent oral poliovirus vaccine (tOPV) containing Sabin poliovirus types 1, 2, and 3 with bivalent OPV containing only Sabin poliovirus types 1 and 3 during April-May 2016, poliovirus type 2 (PV2) is now an eradicated pathogen. However, in eight countries (Cameroon, Chad, Democratic Republic of Congo, Mozambique, Niger, Nigeria, Pakistan, and Syria), monovalent type 2 OPV (mOPV2) was authorized for large-scale outbreak control after tOPV withdrawal (1). Poliovirus containment, an evolving area of work that affects every country, aims to ensure that all PV2 specimens are safely contained to minimize the risk for reintroducing the virus into communities. This report summarizes the current status of poliovirus containment and progress since the last report (2), and outlines remaining challenges. Within 30 countries, 86 facilities have been designated by the relevant national authorities (usually the Ministry of Health) to become poliovirus-essential facilities for the continued storage or handling of PV2 materials; each country is responsible for ensuring that these facilities meet all biorisk management requirements.

摘要

全球根除脊髓灰质炎行动(GPEI)在朝着根除目标不断取得进展。三种血清型中,仅1型野生脊髓灰质炎病毒(WPV1)仍在传播,病例数和地方流行传播的国家数量均处于历史最低水平。随着2015年2型野生脊髓灰质炎病毒(WPV2)根除的认证以及2016年4月至5月期间全球用仅含1型和3型萨宾脊髓灰质炎病毒的二价口服脊髓灰质炎疫苗(bOPV)取代含1型、2型和3型萨宾脊髓灰质炎病毒的三价口服脊髓灰质炎疫苗(tOPV),2型脊髓灰质炎病毒(PV2)现已成为一种被根除的病原体。然而,在八个国家(喀麦隆、乍得、刚果民主共和国、莫桑比克、尼日尔、尼日利亚、巴基斯坦和叙利亚),tOPV停用后,2型单价口服脊髓灰质炎疫苗(mOPV2)被批准用于大规模疫情控制(1)。脊髓灰质炎病毒遏制是一个影响每个国家的不断发展的工作领域,旨在确保所有PV2样本得到安全保存,以尽量降低病毒重新引入社区的风险。本报告总结了脊髓灰质炎病毒遏制的现状以及自上次报告(2)以来取得的进展,并概述了剩余挑战。在30个国家内,相关国家当局(通常是卫生部)指定了86个设施作为脊髓灰质炎病毒关键设施,用于持续储存或处理PV2材料;每个国家负责确保这些设施满足所有生物风险管理要求。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7665/5657795/1895ca712bb1/mm6624a5-F.jpg

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