Department of Biomedical Engineering, Hanyang University, Seoul, South Korea.
Department of Neurology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sci Rep. 2018 Sep 6;8(1):13306. doi: 10.1038/s41598-018-31399-1.
We utilized three-dimensional, surface-based, morphometric analysis to investigate ventricle shape between 2 groups: (1) idiopathic normal-pressure hydrocephalus (INPH) patients who had a positive response to the cerebrospinal fluid tap test (CSFTT) and (2) healthy controls. The aims were (1) to evaluate the location of INPH-related structural abnormalities of the lateral ventricles and (2) to investigate relationships between lateral ventricular enlargement and cortical thinning in INPH patients. Thirty-three INPH patients and 23 healthy controls were included in this study. We used sparse canonical correlation analysis to show correlated regions of ventricular surface expansion and cortical thinning. Significant surface expansion in the INPH group was observed mainly in clusters bilaterally located in the superior portion of the lateral ventricles, adjacent to the high convexity of the frontal and parietal regions. INPH patients showed a significant bilateral expansion of both the temporal horns of the lateral ventricles and the medial aspects of the frontal horns of the lateral ventricles to surrounding brain regions, including the medial frontal lobe. Ventricular surface expansion was associated with cortical thinning in the bilateral orbitofrontal cortex, bilateral rostral anterior cingulate cortex, left parahippocampal cortex, left temporal pole, right insula, right inferior temporal cortex, and right fusiform gyrus. These results suggest that patients with INPH have unique patterns of ventricular surface expansion. Our findings encourage future studies to elucidate the underlying mechanism of lateral ventricular morphometric abnormalities in INPH patients.
我们利用基于三维表面的形态计量学分析方法，对两组患者的脑室形状进行了研究：（1）特发性正常压力脑积水（INPH）患者，其对腰椎穿刺脑脊液检查（CSFTT）有阳性反应；（2）健康对照组。目的是（1）评估 INPH 相关侧脑室结构异常的位置；（2）研究 INPH 患者侧脑室扩大与皮质变薄之间的关系。本研究纳入了 33 例 INPH 患者和 23 名健康对照组。我们使用稀疏典型相关分析来显示脑室表面扩张和皮质变薄的相关区域。在 INPH 组中，明显的脑室扩张主要发生在双侧、位于侧脑室上部、靠近额区和顶区的高凸部的集群中。INPH 患者双侧侧脑室颞角和侧脑室前角的内侧部分均明显扩张，向周围脑区扩展，包括内侧额叶。脑室表面扩张与双侧眶额皮质、双侧额前扣带皮质、左海马旁皮质、左颞极、右岛叶、右下颞叶皮质和右梭状回皮质的皮质变薄有关。这些结果表明，INPH 患者具有独特的脑室表面扩张模式。我们的发现鼓励未来的研究阐明 INPH 患者侧脑室形态异常的潜在机制。
