皮肤癌与维生素D：最新进展
Skin cancer and vitamin D: an update.
作者信息
Wyatt Candy, Neale Rachel E, Lucas Robyn M
机构信息
National Centre for Epidemiology & Population Health, Australian National University, Canberra, Australia.
Telethon Kids Institute, University of Western Australia, Perth, Australia.
出版信息
Melanoma Manag. 2015 Feb;2(1):51-61. doi: 10.2217/mmt.14.31. Epub 2015 Feb 25.
Exposure of the skin to solar ultraviolet (UV) radiation has both risks and benefits for human health. Absorption of UV-B radiation by DNA results in mutations that underlie the development of skin cancers, as is apparent from genetic studies showing high occurrence of UV signature mutations within these tumors. UV-B radiation is also absorbed by 7-dehydrocholesterol to initiate vitamin D synthesis. In experimental studies vitamin D metabolites enhance apoptosis of malignant cells, inhibit angiogenesis and proliferation and increase differentiation, potentially reducing skin cancer development and improving prognosis after diagnosis. There are some supporting human data. We review the links between sun exposure, vitamin D and skin cancers.
皮肤暴露于太阳紫外线（UV）辐射对人类健康既有风险也有益处。DNA对UV-B辐射的吸收会导致突变，而这些突变是皮肤癌发生的基础，这从基因研究中可以明显看出，这些肿瘤内UV特征性突变的发生率很高。UV-B辐射还会被7-脱氢胆固醇吸收以启动维生素D的合成。在实验研究中，维生素D代谢产物可增强恶性细胞的凋亡，抑制血管生成和增殖，并增加分化，有可能减少皮肤癌的发生并改善诊断后的预后。有一些支持性的人体数据。我们综述了阳光照射、维生素D与皮肤癌之间的联系。
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