Bukoski R D, Sparks H V, Mela-Riker L M
Adv Exp Med Biol. 1986;194:157-67. doi: 10.1007/978-1-4684-5107-8_13.
The results from the previous work (Bukoski et al, 1983) and those presented here indicate that mitochondria from rat heart are capable of producing adenosine in concert with a sarcolemmal 5'-nucleotidase. In addition, and perhaps more importantly, these data also indicate that mitochondria can produce adenosine in the presence of inhibition of sarcolemmal 5'-nucleotidase. Given the current understanding of the regulation of mitochondrial respiration and thus oxygen consumption, mitochondria may be uniquely situated to sense increases in myocardial oxygen demand and respond to this with a feedback signal (adenosine) which can return the system to a state of balance.
先前研究（布科斯基等人，1983年）的结果以及此处呈现的结果表明，大鼠心脏的线粒体能够与肌膜5'-核苷酸酶协同产生腺苷。此外，或许更重要的是，这些数据还表明，在线粒体5'-核苷酸酶受到抑制的情况下，线粒体仍能产生腺苷。鉴于目前对线粒体呼吸调节以及由此产生的氧消耗的理解，线粒体可能处于独特的位置来感知心肌需氧量的增加，并以反馈信号（腺苷）做出反应，使系统恢复到平衡状态。
