pukoski R D, Sparks H V, Mela-Riker L M
Biochim Biophys Acta. 1986 Oct 29;884(1):25-30. doi: 10.1016/0304-4165(86)90222-9.
Adenosine production by isolated rat heart mitochondria was examined and was observed to be dependent on an active adenine nucleotide transporter and a functional 5'-nucleotidase. It was found that mitochondria do not transport adenosine. These results suggest that mitochondria provide AMP for an extramitochondrial 5'-nucleotidase and this was verified by direct measurement of extramitochondrial levels of AMP and adenosine. A possible role for mitochondria in myocardial adenosine production is discussed.
对分离出的大鼠心脏线粒体的腺苷生成情况进行了检测，发现其依赖于活性腺嘌呤核苷酸转运体和功能性5'-核苷酸酶。研究发现线粒体不转运腺苷。这些结果表明，线粒体为线粒体外的5'-核苷酸酶提供AMP，这一点通过直接测量线粒体外的AMP和腺苷水平得到了验证。文中讨论了线粒体在心肌腺苷生成中的可能作用。
