大鼠多形核白细胞内腺苷的产生
Adenosine production inside rat polymorphonuclear leucocytes.
作者信息
Newby A C, Holmquist C A
出版信息
Biochem J. 1981 Nov 15;200(2):399-403. doi: 10.1042/bj2000399.
Abstract
Adenosine synthesis was studied during 2-deoxyglucose-induced ATP catabolism in intact rat polymorphonuclear leucocytes. When both adenosine kinase (EC 2.7.1.20) and adenosine deaminase (EC 3.5.4.4) were selectively inhibited, adenosine accumulated. Adenosine formation took place inside the intact cells by a metabolic pathway independent of the ecto-5'-nucleotidase (EC 3.1.3.5). Distinct metabolic pathways are proposed for adenosine production from intracellular or extracellular nucleotides.
摘要
在完整大鼠多形核白细胞中，研究了2-脱氧葡萄糖诱导的ATP分解代谢过程中的腺苷合成。当腺苷激酶（EC 2.7.1.20）和腺苷脱氨酶（EC 3.5.4.4）均被选择性抑制时，腺苷会积累。腺苷的形成通过一条独立于胞外5'-核苷酸酶（EC 3.1.3.5）的代谢途径在完整细胞内发生。针对由细胞内或细胞外核苷酸产生腺苷提出了不同的代谢途径。
相似文献
1
Adenosine production inside rat polymorphonuclear leucocytes.大鼠多形核白细胞内腺苷的产生
Biochem J. 1981 Nov 15;200(2):399-403. doi: 10.1042/bj2000399.
2
Role of adenosine deaminase, ecto-(5'-nucleotidase) and ecto-(non-specific phosphatase) in cyanide-induced adenosine monophosphate catabolism in rat polymorphonuclear leucocytes.腺苷脱氨酶、胞外（5'-核苷酸酶）和胞外（非特异性磷酸酶）在氰化物诱导的大鼠多形核白细胞单磷酸腺苷分解代谢中的作用
Biochem J. 1980 Mar 15;186(3):907-18. doi: 10.1042/bj1860907.
3
The control of adenosine concentration in polymorphonuclear leucocytes, cultured heart cells and isolated perfused heart from the rat.大鼠多形核白细胞、培养的心脏细胞和离体灌注心脏中腺苷浓度的控制。
Biochem J. 1983 Aug 15;214(2):317-23. doi: 10.1042/bj2140317.
4
The mechanism of adenosine production in rat polymorphonuclear leucocytes.大鼠多形核白细胞中腺苷生成的机制。
Biochem J. 1983 Aug 15;214(2):325-30. doi: 10.1042/bj2140325.
5
Inhibition of IMP-specific cytosolic 5'-nucleotidase and adenosine formation in rat polymorphonuclear leucocytes by 5'-deoxy-5'-isobutylthio derivatives of adenosine and inosine.腺苷和肌苷的5'-脱氧-5'-异丁硫基衍生物对大鼠多形核白细胞中IMP特异性胞质5'-核苷酸酶及腺苷生成的抑制作用
Biochem J. 1989 Aug 15;262(1):203-8. doi: 10.1042/bj2620203.
6
Pathways of adenine nucleotide catabolism in primary rat muscle cultures.原代大鼠肌肉培养物中腺嘌呤核苷酸分解代谢的途径。
Biochim Biophys Acta. 1987 Dec 7;926(3):287-95. doi: 10.1016/0304-4165(87)90215-7.
7
Absolute rates of adenosine formation during ischaemia in rat and pigeon hearts.大鼠和鸽心脏缺血期间腺苷形成的绝对速率。
Biochem J. 1988 Feb 1;249(3):695-703. doi: 10.1042/bj2490695.
8
Activation of protein kinase C increases adenosine production in the hypoxic canine coronary artery through the extracellular pathway.蛋白激酶C的激活通过细胞外途径增加缺氧犬冠状动脉中的腺苷生成。
Arterioscler Thromb Vasc Biol. 1995 Dec;15(12):2298-304. doi: 10.1161/01.atv.15.12.2298.
9
Mechanism of deoxyadenosine-induced catabolism of adenine ribonucleotides in adenosine deaminase-inhibited human T lymphoblastoid cells.脱氧腺苷在腺苷脱氨酶抑制的人T淋巴母细胞中诱导腺嘌呤核糖核苷酸分解代谢的机制。
Proc Natl Acad Sci U S A. 1982 Apr;79(8):2673-7. doi: 10.1073/pnas.79.8.2673.
10
Mechanisms of elevation of adenosine levels in anoxic hepatocytes.缺氧肝细胞中腺苷水平升高的机制。
Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):671-7. doi: 10.1042/bj2900671.
引用本文的文献
1
Concentrative Nucleoside Transporter, CNT, Results in Selective Toxicity of Toyocamycin against Candida albicans.集中核苷转运蛋白（CNT）导致托洛霉素对白色念珠菌的选择性毒性。
Microbiol Spectr. 2022 Aug 31;10(4):e0113822. doi: 10.1128/spectrum.01138-22. Epub 2022 Aug 1.
2
Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension.腺苷受体作为治疗肺动脉高压的药物靶点
Front Pharmacol. 2017 Dec 4;8:858. doi: 10.3389/fphar.2017.00858. eCollection 2017.
3
Regulation of neutrophil function by adenosine.腺苷对中性粒细胞功能的调节。
Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):856-64. doi: 10.1161/ATVBAHA.111.226845.
4
Quantitative contribution of the acid production to the intracellular acidification in human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine.N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸刺激人中性粒细胞时，酸产生对细胞内酸化的定量贡献。
Mol Cell Biochem. 1995 Nov 22;152(2):159-65. doi: 10.1007/BF01076078.
5
A new procedure for haptenizing adenosine leading to a more specific radioimmunoassay method.一种使腺苷半抗原化的新方法，该方法可产生更特异的放射免疫分析方法。
Biochem J. 1982 Dec 15;208(3):603-10. doi: 10.1042/bj2080603.
6
Energy metabolism of human neutrophils during phagocytosis.吞噬作用期间人类中性粒细胞的能量代谢
J Clin Invest. 1982 Sep;70(3):550-7. doi: 10.1172/jci110647.
7
Intracellular adenosine in isolated rat liver cells.
Pflugers Arch. 1984 Jan;400(1):106-8. doi: 10.1007/BF00670544.
8
The control of adenosine concentration in polymorphonuclear leucocytes, cultured heart cells and isolated perfused heart from the rat.大鼠多形核白细胞、培养的心脏细胞和离体灌注心脏中腺苷浓度的控制。
Biochem J. 1983 Aug 15;214(2):317-23. doi: 10.1042/bj2140317.
9
Ferritin immunoelectron microscopic localization of 5'-nucleotidase on rat liver cell surface.大鼠肝细胞表面5'-核苷酸酶的铁蛋白免疫电子显微镜定位
J Cell Biol. 1984 Jul;99(1 Pt 1):166-73. doi: 10.1083/jcb.99.1.166.
10
The mechanism of adenosine production in rat polymorphonuclear leucocytes.大鼠多形核白细胞中腺苷生成的机制。
Biochem J. 1983 Aug 15;214(2):325-30. doi: 10.1042/bj2140325.
本文引用的文献
1
REGULATION OF CORONARY BLOOD FLOW.冠状动脉血流的调节
Physiol Rev. 1964 Jan;44:1-29. doi: 10.1152/physrev.1964.44.1.1.
2
The interaction of inhibitors with adenosine metabolising enzymes in intact isolated cells.抑制剂与完整分离细胞中腺苷代谢酶的相互作用。
Biochem Pharmacol. 1981 Sep 15;30(18):2611-5. doi: 10.1016/0006-2952(81)90589-x.
3
Role of S-adenosylhomocysteine hydrolase in adenosine metabolism in mammalian heart.S-腺苷同型半胱氨酸水解酶在哺乳动物心脏腺苷代谢中的作用。
Biochem J. 1981 Apr 15;196(1):65-70. doi: 10.1042/bj1960065.
4
Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture.培养的血管内皮细胞和平滑肌细胞外切酶对腺嘌呤核苷酸的代谢
Biochem J. 1980 Aug 15;190(2):421-9. doi: 10.1042/bj1900421.
5
The role of adenosine in the regulation of coronary blood flow.腺苷在冠状动脉血流调节中的作用。
Circ Res. 1980 Dec;47(6):807-13. doi: 10.1161/01.res.47.6.807.
6
Role of adenosine deaminase, ecto-(5'-nucleotidase) and ecto-(non-specific phosphatase) in cyanide-induced adenosine monophosphate catabolism in rat polymorphonuclear leucocytes.腺苷脱氨酶、胞外（5'-核苷酸酶）和胞外（非特异性磷酸酶）在氰化物诱导的大鼠多形核白细胞单磷酸腺苷分解代谢中的作用
Biochem J. 1980 Mar 15;186(3):907-18. doi: 10.1042/bj1860907.
7
Subcellular distribution and movement of 5'-nucleotidase in rat cells.大鼠细胞中5'-核苷酸酶的亚细胞分布与移动
Biochem J. 1980 Jan 15;186(1):59-69. doi: 10.1042/bj1860059.
8
Nucleotide biosynthesis from preformed purines in mammalian cells: regulatory mechanisms and biological significance.哺乳动物细胞中由预先形成的嘌呤进行核苷酸生物合成：调控机制与生物学意义。
Prog Nucleic Acid Res Mol Biol. 1970;10:87-119. doi: 10.1016/s0079-6603(08)60562-0.
9
Ecto-enzymes of the guinea pig polymorphonuclear leukocyte. II. Properties and suitability as markers for the plasma membrane.豚鼠多形核白细胞的外切酶。II. 作为质膜标记物的特性及适用性
J Biol Chem. 1974 Nov 25;249(22):7121-9.
10
Adenosine release from isolated fat cells and its significance for the effects of hormones on cyclic 3',5'-AMP levels and lipolysis.从分离的脂肪细胞中释放的腺苷及其对激素影响环3',5'-腺苷酸水平和脂肪分解的意义。
Naunyn Schmiedebergs Arch Pharmacol. 1973;276(2):133-48. doi: 10.1007/BF00501186.
Zotero 插件