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Biochem J. 1981 Nov 15;200(2):399-403. doi: 10.1042/bj2000399.
2
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10
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REGULATION OF CORONARY BLOOD FLOW.冠状动脉血流的调节
Physiol Rev. 1964 Jan;44:1-29. doi: 10.1152/physrev.1964.44.1.1.
2
The interaction of inhibitors with adenosine metabolising enzymes in intact isolated cells.抑制剂与完整分离细胞中腺苷代谢酶的相互作用。
Biochem Pharmacol. 1981 Sep 15;30(18):2611-5. doi: 10.1016/0006-2952(81)90589-x.
3
Role of S-adenosylhomocysteine hydrolase in adenosine metabolism in mammalian heart.S-腺苷同型半胱氨酸水解酶在哺乳动物心脏腺苷代谢中的作用。
Biochem J. 1981 Apr 15;196(1):65-70. doi: 10.1042/bj1960065.
4
Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture.培养的血管内皮细胞和平滑肌细胞外切酶对腺嘌呤核苷酸的代谢
Biochem J. 1980 Aug 15;190(2):421-9. doi: 10.1042/bj1900421.
5
The role of adenosine in the regulation of coronary blood flow.腺苷在冠状动脉血流调节中的作用。
Circ Res. 1980 Dec;47(6):807-13. doi: 10.1161/01.res.47.6.807.
6
Role of adenosine deaminase, ecto-(5'-nucleotidase) and ecto-(non-specific phosphatase) in cyanide-induced adenosine monophosphate catabolism in rat polymorphonuclear leucocytes.腺苷脱氨酶、胞外（5'-核苷酸酶）和胞外（非特异性磷酸酶）在氰化物诱导的大鼠多形核白细胞单磷酸腺苷分解代谢中的作用
Biochem J. 1980 Mar 15;186(3):907-18. doi: 10.1042/bj1860907.
7
Subcellular distribution and movement of 5'-nucleotidase in rat cells.大鼠细胞中5'-核苷酸酶的亚细胞分布与移动
Biochem J. 1980 Jan 15;186(1):59-69. doi: 10.1042/bj1860059.
8
Nucleotide biosynthesis from preformed purines in mammalian cells: regulatory mechanisms and biological significance.哺乳动物细胞中由预先形成的嘌呤进行核苷酸生物合成：调控机制与生物学意义。
Prog Nucleic Acid Res Mol Biol. 1970;10:87-119. doi: 10.1016/s0079-6603(08)60562-0.
9
Ecto-enzymes of the guinea pig polymorphonuclear leukocyte. II. Properties and suitability as markers for the plasma membrane.豚鼠多形核白细胞的外切酶。II. 作为质膜标记物的特性及适用性
J Biol Chem. 1974 Nov 25;249(22):7121-9.
10
Adenosine release from isolated fat cells and its significance for the effects of hormones on cyclic 3',5'-AMP levels and lipolysis.从分离的脂肪细胞中释放的腺苷及其对激素影响环3',5'-腺苷酸水平和脂肪分解的意义。
Naunyn Schmiedebergs Arch Pharmacol. 1973;276(2):133-48. doi: 10.1007/BF00501186.

大鼠多形核白细胞内腺苷的产生

Adenosine production inside rat polymorphonuclear leucocytes.

作者信息

Newby A C, Holmquist C A

出版信息

Biochem J. 1981 Nov 15;200(2):399-403. doi: 10.1042/bj2000399.

DOI:10.1042/bj2000399
PMID:6280685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1163548/
Abstract

Adenosine synthesis was studied during 2-deoxyglucose-induced ATP catabolism in intact rat polymorphonuclear leucocytes. When both adenosine kinase (EC 2.7.1.20) and adenosine deaminase (EC 3.5.4.4) were selectively inhibited, adenosine accumulated. Adenosine formation took place inside the intact cells by a metabolic pathway independent of the ecto-5'-nucleotidase (EC 3.1.3.5). Distinct metabolic pathways are proposed for adenosine production from intracellular or extracellular nucleotides.

摘要

在完整大鼠多形核白细胞中，研究了2-脱氧葡萄糖诱导的ATP分解代谢过程中的腺苷合成。当腺苷激酶（EC 2.7.1.20）和腺苷脱氨酶（EC 3.5.4.4）均被选择性抑制时，腺苷会积累。腺苷的形成通过一条独立于胞外5'-核苷酸酶（EC 3.1.3.5）的代谢途径在完整细胞内发生。针对由细胞内或细胞外核苷酸产生腺苷提出了不同的代谢途径。