Rao Suresh Ranga, Ajitkumar Supraja, Subbarayan Rajasekaran, Girija Dinesh Murugan
Department of Periodontology and Implantology, Faculty of Dental Sciences & Centre for Regenerative Medicine and Stem Cell Research, Sri Ramachandra University, Chennai, India.
Centre for Regenerative Medicine and Stem Cell Research, Central Research Facility, Sri Ramachandra University, Chennai, India.
J Oral Biol Craniofac Res. 2018 Sep-Dec;8(3):165-167. doi: 10.1016/j.jobcr.2016.11.002. Epub 2016 Dec 22.
Drug induced gingival overgrowth is one of the side effects affecting the gingiva due to administration of certain systemic drugs. Cyclosporine A is one such drug which is commonly used in organ transplant conditions. The resultant overgrowth is fibrotic and extensive in nature which could impair patient esthetics and masticatory function. Endoplasmic reticulum stress is a recently identified phenomenon implicated in other fibrotic pathologies such as lung and renal fibrosis. In fact, endoplasmic reticulum stress has been known to play an important role in cyclosporine A induced renal fibrosis. Thus in this study, we sought to identify it's role in drug induced gingival overgrowth.
药物性牙龈增生是由于使用某些全身性药物而影响牙龈的副作用之一。环孢素A就是这样一种常用于器官移植情况的药物。由此产生的增生本质上是纤维化且广泛的，可能会损害患者的美观和咀嚼功能。内质网应激是最近发现的一种现象，与其他纤维化病理如肺纤维化和肾纤维化有关。事实上，内质网应激在环孢素A诱导的肾纤维化中已被认为起着重要作用。因此，在本研究中，我们试图确定其在药物性牙龈增生中的作用。
