Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2019 Mar;234(3):2277-2295. doi: 10.1002/jcp.27205. Epub 2018 Sep 7.
Inflammation is a normal part of the immune response to injury or infection but its dysregulation promotes the development of inflammatory diseases, which cause considerable human suffering. Nonsteroidal anti-inflammatory agents are the most commonly prescribed agents for the treatment of inflammatory diseases, but they are accompanied by a broad range of side effects, including gastrointestinal and cardiovascular events. The renin-angiotensin system (RAS) is traditionally known for its role in blood pressure regulation. However, there is increasing evidence that RAS signaling is also involved in the inflammatory response associated with several disease states. Angiotensin II increases blood pressure by binding to angiotensin type 1 (AT ) receptor, and direct renin inhibitors, angiotensin-converting enzyme (ACE) inhibitors and AT receptor blockers (ARBs) are clinically used as antihypertensive agents. Recent data suggest that these drugs also have anti-inflammatory effects. Therefore, this review summarizes these recent findings for the efficacy of two of the most widely used antihypertensive drug classes, ACE inhibitors and ARBs, to reduce or treat inflammatory diseases such as atherosclerosis, arthritis, steatohepatitis, colitis, pancreatitis, and nephritis.
炎症是机体对损伤或感染的正常免疫反应的一部分，但它的失调会促进炎症性疾病的发展，这些疾病会给人类带来巨大的痛苦。非甾体抗炎药是治疗炎症性疾病最常用的药物，但它们伴随着广泛的副作用，包括胃肠道和心血管事件。肾素-血管紧张素系统（RAS）传统上以其在血压调节中的作用而闻名。然而，越来越多的证据表明，RAS 信号也参与了与几种疾病状态相关的炎症反应。血管紧张素 II 通过与血管紧张素类型 1（AT1）受体结合来升高血压，而直接肾素抑制剂、血管紧张素转换酶（ACE）抑制剂和 AT 受体阻滞剂（ARB）被临床用作抗高血压药物。最近的数据表明，这些药物也具有抗炎作用。因此，本综述总结了这两种最广泛使用的抗高血压药物类别（ACE 抑制剂和 ARB）的最近研究结果，以减轻或治疗炎症性疾病，如动脉粥样硬化、关节炎、脂肪性肝炎、结肠炎、胰腺炎和肾炎。
