Molecular Synthesis and Drug Discovery Laboratory, Centre of Biomedical Research , Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow - 226014 , India.
Org Lett. 2018 Sep 21;20(18):5861-5865. doi: 10.1021/acs.orglett.8b02537. Epub 2018 Sep 7.
A straightforward synthesis of amides, ureas, and esters is reported by visible-light cross-dehydrogenating coupling (CDC) of aldehydes (or amine carbaldehydes) and amines/R-OTBS ethers by photoredox catalysis. The reaction is found to be general and high yielding. A plausible mechanistic pathway has been proposed for these transformations and is supported by appropriate controlled experiments.
通过光氧化还原催化，报告了一种醛（或胺醛）和胺/R-OTBS 醚的可见光交叉脱氢偶联（CDC），实现酰胺、脲和酯的直接合成。该反应具有普遍适用性和高产率。为这些转化提出了一个合理的可能的机理途径，并通过适当的对照实验得到了支持。
