Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mol Cell. 2018 Sep 6;71(5):649-651. doi: 10.1016/j.molcel.2018.08.032.
In this issue of Molecular Cell, McGurk et al. (2018) identify how poly(ADP-ribose) binding tunes the phase behavior of the ALS disease protein TDP-43, uncovering the molecular events underlying its aggregation in disease and illuminating a novel therapeutic target.
在本期《分子细胞》中，麦格克等人（2018 年）鉴定了多聚（ADP-核糖）结合如何调节 ALS 疾病蛋白 TDP-43 的相行为，揭示了其在疾病中聚集的分子事件，并阐明了一个新的治疗靶点。
