Measuring the Impact of Nonignorable Missingness Using the R Package isni.

BACKGROUND AND OBJECTIVE

The popular assumption of ignorability simplifies analyses with incomplete data, but if it is not satisfied, results may be incorrect. Therefore it is necessary to assess the sensitivity of empirical findings to this assumption. We have created a user-friendly and freely available software program to conduct such analyses.

METHOD

One can evaluate the dependence of inferences on the assumption of ignorability by measuring their sensitivity to its violation. One tool for such an analysis is the index of local sensitivity to nonignorability (ISNI), which evaluates the rate of change of parameter estimates to the assumed degree of nonignorability in the neighborhood of an ignorable model. Computation of ISNI avoids the need to estimate a nonignorable model or to posit a specific magnitude of nonignorability. Our new R package, named isni, implements ISNI analysis for some common data structures and corresponding statistical models.

RESULT

The isni package computes ISNI in the generalized linear model for independent data, and in the marginal multivariate Gaussian model and the linear mixed model for longitudinal/clustered data. It allows for arbitrary patterns of missingness caused by dropout and/or intermittent missingness. Examples illustrate its use and features.

CONCLUSIONS

The R package isni enables a systematic and efficient sensitivity analysis that informs evaluations of reliability and validity of empirical findings from incomplete data.