1 School of Human Science and Environment, University of Hyogo, Hyogo 6700092, Japan.
2 Next Generation Science Institute, Morinaga Milk Industry Co., Ltd., Kanagawa 2528583, Japan.
Benef Microbes. 2018 Dec 7;9(6):843-853. doi: 10.3920/BM2017.0193. Epub 2018 Sep 10.
Physical exercise exerts favourable effects on brain health and quality of life of the elderly; some of these positive health effects are induced by the modulation of microbiota composition. We therefore conducted a randomised, double blind, placebo-controlled trial that assessed whether a combination of spp. supplementation and moderate resistance training improved the cognitive function and other health-related parameters in healthy elderly subjects. Over a 12-week period, 38 participants (66-78 years) underwent resistance training and were assigned to the probiotic supplementation (n=20; 1.25×10 cfu each of subsp. BB536, subsp. M-63, M-16V and B-3) or the placebo (n=18) group. At baseline and at 12 weeks, we assessed the cognitive function, using the Japanese version of the Montreal Cognitive Assessment instrument (MoCA-J); modified flanker task scores; depression-anxiety scores; body composition; and bowel habits. At 12 weeks, the MoCA-J scores showed a significant increase in both the groups, while the flanker task scores of the probiotic group increased more significantly than those of the placebo group (0.35±0.9 vs -0.29±1.1, =0.056). Only the probiotic group showed a significant decrease in the depression-anxiety scores (5.2±6.3 to 3.4±5.5, =0.012) and body mass index (24.0±2.8 to 23.5±2.8 kg/m, <0.001), with a significant increase in the defecation frequency (5.3±2.3 to 6.4±2.3 times/5 days, =0.023) at 12 weeks. Thus, in healthy elderly subjects, combined probiotic bifidobacteria supplementation and moderate resistance training may improve the mental condition, body weight and bowel movement frequency.
体育锻炼对老年人的大脑健康和生活质量有有益影响；其中一些积极的健康影响是通过调节微生物群落组成来诱导的。因此，我们进行了一项随机、双盲、安慰剂对照试验，评估了 spp. 补充剂和中等强度的抗阻训练是否改善了健康老年人的认知功能和其他健康相关参数。在 12 周的时间里，38 名参与者（66-78 岁）接受了抗阻训练，并被分配到益生菌补充剂（n=20；每种亚种 1.25×10 cfu）或安慰剂（n=18）组。在基线和 12 周时，我们使用日本版蒙特利尔认知评估工具（MoCA-J）评估了认知功能；改良的侧抑制任务评分；抑郁焦虑评分；身体成分；和排便习惯。在 12 周时，两组的 MoCA-J 评分均显著增加，而益生菌组的侧抑制任务评分增加幅度明显大于安慰剂组（0.35±0.9 与-0.29±1.1，=0.056）。只有益生菌组的抑郁焦虑评分（5.2±6.3 至 3.4±5.5，=0.012）和体重指数（24.0±2.8 至 23.5±2.8 kg/m，<0.001）显著降低，排便频率（5.3±2.3 至 6.4±2.3 次/5 天，=0.023）显著增加。因此，在健康的老年人群中，联合益生菌双歧杆菌补充剂和中等强度的抗阻训练可能改善精神状态、体重和排便频率。
