Weisser J, Wiedemann B
Infection. 1986;14 Suppl 3:S183-5. doi: 10.1007/BF01667839.
DNA gyrase is an essential enzyme in bacterial metabolism. Its function is the introduction of negative supercoils into DNA. These favour the unwinding of certain parts of DNA und thus are likely to facilitate processes like replication and transcription. Inhibition of DNA gyrase by quinolones and possible effects on the structure of DNA are reviewed.
DNA促旋酶是细菌新陈代谢中的一种必需酶。其功能是将负超螺旋引入DNA。这些负超螺旋有利于DNA某些部分的解旋，因此可能促进复制和转录等过程。本文综述了喹诺酮类药物对DNA促旋酶的抑制作用及其对DNA结构可能产生的影响。
