[4-喹诺酮类对回旋酶的抑制作用：对DNA结构的影响]
[Inhibition of gyrase by 4-quinolones: effect on the structure of DNA].
作者信息
Weisser J, Wiedemann B
出版信息
Infection. 1986;14 Suppl 3:S183-5. doi: 10.1007/BF01667839.
PMID:3019897
Abstract
DNA gyrase is an essential enzyme in bacterial metabolism. Its function is the introduction of negative supercoils into DNA. These favour the unwinding of certain parts of DNA und thus are likely to facilitate processes like replication and transcription. Inhibition of DNA gyrase by quinolones and possible effects on the structure of DNA are reviewed.
摘要
DNA促旋酶是细菌新陈代谢中的一种必需酶。其功能是将负超螺旋引入DNA。这些负超螺旋有利于DNA某些部分的解旋，因此可能促进复制和转录等过程。本文综述了喹诺酮类药物对DNA促旋酶的抑制作用及其对DNA结构可能产生的影响。
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本文引用的文献
1
DNA supercoiling by DNA gyrase.
Nature. 1981 Dec 17;294(5842):607-8. doi: 10.1038/294607a0.
2
DNA gyrase and the supercoiling of DNA.DNA 回旋酶与 DNA 的超螺旋化
Science. 1980 Feb 29;207(4434):953-60. doi: 10.1126/science.6243420.
3
Mutational resistance to 4-quinolone antibacterial agents.对4-喹诺酮类抗菌药物的突变耐药性。
Eur J Clin Microbiol. 1984 Aug;3(4):347-50. doi: 10.1007/BF01977492.
4
Selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes.喹诺酮类、β-内酰胺类和氨基糖苷类药物对多重抗生素耐药性的选择，特别提及不相关药物类别之间的交叉耐药性。
Antimicrob Agents Chemother. 1984 Dec;26(6):797-801. doi: 10.1128/AAC.26.6.797.
5
Elimination of plasmids by new 4-quinolones.新型4-喹诺酮类药物对质粒的消除作用
Antimicrob Agents Chemother. 1985 Nov;28(5):700-2. doi: 10.1128/AAC.28.5.700.
6
Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.新生霉素和香豆霉素抑制由DNA促旋酶催化的DNA超螺旋化。
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4474-8. doi: 10.1073/pnas.73.12.4474.
7
DNA gyrase on the bacterial chromosome: DNA cleavage induced by oxolinic acid.细菌染色体上的DNA回旋酶：恶喹酸诱导的DNA切割
J Mol Biol. 1979 Jun 25;131(2):287-302. doi: 10.1016/0022-2836(79)90077-9.
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