近红外半导体聚合物刷和 pH/GSH 响应型多金属氧酸盐簇杂化平台用于增强肿瘤特异性光热治疗。
Near-Infrared Semiconducting Polymer Brush and pH/GSH-Responsive Polyoxometalate Cluster Hybrid Platform for Enhanced Tumor-Specific Phototheranostics.
机构信息
Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Engineering and Technology Research Center for Xenotransplantation of Human Province, Changsha, Hunan, China.
出版信息
Angew Chem Int Ed Engl. 2018 Oct 22;57(43):14101-14105. doi: 10.1002/anie.201808074. Epub 2018 Oct 8.
Abstract
Tumor-specific phototheranostics is conducive to realizing precise cancer therapy. Herein, a novel tumor microenvironment (TME)-responsive phototheranostic paradigm based on the combination of semiconducting polymer brushes and polyoxometalate clusters (SPB@POM) is rationally designed. The acidic TME could drive the self-assembly of SPB@POM into bigger aggregates for enhanced tumor retention and accumulation, while the reducing TME could significantly enhance the NIR absorption of SPB@POM for significant improvement of photoacoustic imaging contrast and photothermal therapy efficacy. Therefore, the smart pH/glutathione (GSH)-responsive SPB@POM allows for remarkable phototheranostic enhancement under the unique TME, which has potential for precise tumor-specific phototheranostics with minimal side effects.
摘要
肿瘤特异性光疗有助于实现精确的癌症治疗。在此，基于半导体聚合物刷和多金属氧酸盐簇（SPB@POM）的组合，合理设计了一种新型的肿瘤微环境（TME）响应光疗范例。酸性 TME 可以驱动 SPB@POM 自组装成更大的聚集体，以增强肿瘤的保留和积累，而还原 TME 可以显著增强 SPB@POM 的近红外吸收，从而显著提高光声成像对比度和光热治疗效果。因此，智能 pH/谷胱甘肽（GSH）响应的 SPB@POM 在独特的 TME 下允许显著的光疗增强，具有最小副作用的精确肿瘤特异性光疗的潜力。
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