Department of Laboratory Medicine, Children's Hospital of Shanxi Province, Taiyuan, China.
Department of Laboratory Medicine, Shanxi Provincial People's Hospital, Taiyuan, China.
Colorectal Dis. 2018 Nov;20(11):961-969. doi: 10.1111/codi.14416. Epub 2018 Oct 1.
Human papillomavirus (HPV) infection has been reported in colorectal cancer in many studies. We conducted a meta-analysis to assess the association between HPV infection and colorectal cancer/adenomas in the Chinese population.
Relevant studies up to January 2018 were searched in PubMed, EMBASE, China National Knowledge Infrastructure and the Wanfang database. We used a random effects model to determine the prevalence of HPV and odds ratios (ORs) with 95% confidence intervals (CIs). The I statistic and P-value from the Cochrane Q-test were used to describe the heterogeneity.
Ten case-control studies involving 766 colorectal cancer patients and 470 controls were included in the meta-analysis. Among the colorectal cancer patients, the pooled prevalence was 0.45 (95% CI 0.36-0.53). The pooled estimate for OR was 10.78 (95% CI 4.22, 27.53). Among the 193 patients with colorectal adenoma, the pooled prevalence and OR were 0.31 (95% CI 0.24-0.37) and 2.03 (95% CI 0.79, 5.26), respectively. The prevalence of HPV 16 and HPV 18 among HPV-positive cancers ranged from 57.9% to 100% and 0% to 39.7%, respectively.
The results indicated that HPV infection, especially HPV 16 and HPV 18, is associated with colorectal cancer in the Chinese population.
许多研究报告称，人乳头瘤病毒（HPV）感染与结直肠癌有关。我们进行了一项荟萃分析，以评估 HPV 感染与中国人群结直肠癌/腺瘤之间的关联。
在 PubMed、EMBASE、中国知网和万方数据库中检索截至 2018 年 1 月的相关研究。我们使用随机效应模型来确定 HPV 的流行率和优势比（OR）及其 95%置信区间（CI）。Cochrane Q 检验的 I ²统计量和 P 值用于描述异质性。
纳入了 10 项病例对照研究，共涉及 766 例结直肠癌患者和 470 例对照。在结直肠癌患者中，汇总的流行率为 0.45（95%CI 0.36-0.53）。OR 的汇总估计值为 10.78（95%CI 4.22, 27.53）。在 193 例结直肠腺瘤患者中，汇总的流行率和 OR 分别为 0.31（95%CI 0.24-0.37）和 2.03（95%CI 0.79, 5.26）。HPV 阳性癌症中 HPV 16 和 HPV 18 的流行率分别为 57.9%-100%和 0%-39.7%。
结果表明，HPV 感染，特别是 HPV 16 和 HPV 18，与中国人群的结直肠癌有关。
